Group: STE
Parent of:
STE7 , STE11 , STE-Unique , STE20 ,
Description:
MAP Kinase cascade kinases, homologs of yeast Ste7 (MAP2K), Ste11 (MAP3K) and Ste20 (MAP4K) kinases. The Raf family of MAP4K is structurally distinct from the Ste20 family, and is contained in the TKL group.
Kinase with mutated hotspots in Group:STE
Uniprot ID
Gene symbol
Gatekeeper location
G loop location
A loop location
αC-Helix location
Q02750 MAP2K1 143 207...228 74...83 105...115 P36507 MAP2K2 147 211...232 78...87 110...119 P46734 MAP2K3 140 207...222, 224...229 [N/A] [N/A] P45985 MAP2K4 178 246...268 108...114 139...153 Q13163 MAP2K5 241 300...321 [N/A] [N/A] P52564 MAP2K6 129 196...211, 213...218 59...65 90...104 O14733 MAP2K7 196 260...282 [N/A] 157...172 Q13233 MAP3K1 1323 1387...1414 [N/A] [N/A] Q99558 MAP3K14 469 533...561 406...412 433...435 Q56UN5 MAP3K19 1140 1203...1213, 1221...1232 [N/A] [N/A] Q9Y2U5 MAP3K2 [N/A] 500...526 [N/A] [N/A] Q99683 MAP3K5 754 821...844 686...695 725...729 O95382 MAP3K6 722 789...812 [N/A] [N/A] P41279 MAP3K8 207 269...292 [N/A] 171...173 Q92918 MAP4K1 91 154...165, 168...177 [N/A] [N/A] Q8IVH8 MAP4K3 90 153...164, 167...176 22...28 56...66 O95819 MAP4K4 105 [N/A] 31...37 63...73 Q8N4C8 MINK1 105 170...193 [N/A] [N/A] Q8NEV4 MYO3A 100 167...190 [N/A] [N/A] Q8WXR4 MYO3B 106 173...196 [N/A] [N/A] O95747 OXSR1 92 163...176, 183...191 22...33 57...65 Q13153 PAK1 [N/A] [N/A] 277...284 303...305 O96013 PAK4 395 457...480 327...333 354...356 Q9P286 PAK5 523 585...608 455...461 482...484 Q9NQU5 PAK6 481 543...566 414...421 446...448 Q9H2G2 SLK 108 172...195 38...48 41...43 O94804 STK10 110 174...197 [N/A] 75...87 Q9Y6E0 STK24 111 173...184, 186...196 42...48 76...88 O00506 STK25 95 157...180 26...32 60...72 Q9P289 STK26 99 161...184 30...36 63...74 Q13188 STK3 99 163...175, 177...186 32...42 64...76 Q9UEW8 STK39 138 209...222, 229...237 [N/A] [N/A] Q13043 STK4 102 166...178, 180...189 33...45 68...78 Q7RTN6 STRADA 147 [N/A] [N/A] 104...106 Q9C0K7 STRADB 136 [N/A] [N/A] [N/A] Q7L7X3 TAOK1 105 168...187 [N/A] [N/A] Q9UL54 TAOK2 105 168...187 [N/A] [N/A] Q9H2K8 TAOK3 101 164...183 [N/A] [N/A] Q9UKE5 TNIK 105 170...193 32...39 63...76