DegronMD

Uniprot ID: P23468

Source protein: Receptor-type tyrosine-protein phosphatase delta

Source gene: PTPRD

Class: DEG_SPOP_SBC_1

Location: 621:625

E3 ligase: SPOP

DEGRON score: 0.9072

ASA_SCORE: 49.66

COIL: 0.7354

CONS_SCORE: 0.6075

DSS_SCORE: 0.5341

HELIX: 0.0166

FCONS_SCORE: 0.9753

RIG_SCORE: 0.6451

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S623F	TCGA-06-5416	GBM	TCGA	PSSTS	DEG_SPOP_SBC_1	0.7982
p.S623F	TCGA-DU-6392	LGG	TCGA	PSSTS	DEG_SPOP_SBC_1	0.7982
p.S623F	DO10880	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7982
p.S623F	DO22237	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7982
p.S623F	SIDM00789	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	0.7982
p.S623F	ACH-000997	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	0.7982
p.S623F	HCT-15	large_intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	0.7982
p.P621Q	TCGA-CN-A499	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	0.7035
p.P621Q	DO52040	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7035
p.S625T	TCGA-E7-A7XN	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	0.6005
p.P621L	TCGA-GF-A4EO	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	0.7582
p.S612T	DO51878	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.0833
p.E631D	DO48566	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.1667
p.E631D	DO52426	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	0.1667
p.N626S	DO228314	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.3056
p.H614D	DO1663	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.1389
p.V615A	DO9002	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	0.1667
p.V623M	DO222762	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7208
p.V623M	DO43426	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7208
p.K624N	DO50441	ESAD	ICGC	PSSTS	DEG_SPOP_SBC_1	0.6918
p.A617S	DO11411	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	0.2222
p.Q625K	DO228948	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.6944
p.P635H	DO229019	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.0556
p.E628Q	DO45346	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	0.25
p.W624R	DO23590	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	0.8634
p.E623K	DO220903	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7022
p.E623K	DO220906	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.7022
p.H611Y	DO222494	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.0556
p.H611Y	DO37607	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	0.0556
p.P635T	DO222413	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.0556
p.P635T	DO229221	THCA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.0556
p.P627S	DO222908	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	0.2778
p.S626F	DO37839	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	0.3056
p.I628T	DO38192	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	0.25
p.S623Y	DO43186	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	0.712
p.Q614E	HUH-6-clone5	liver	COSMIC	PSSTS	DEG_SPOP_SBC_1	0.1389
p.L615V	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	0.1667
p.L620V	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	0.3056
p.L622V	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	0.6765
p.L625V	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43426	Synaptojanin-1	DEG_SPOP_SBC_1	991:995	PSSTS	SPOP	0.8023	More...
O75563	Src kinase-associated phosphoprotein 2	DEG_SPOP_SBC_1	4:8	PSSTS	SPOP	0.9465	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	304:308	PSSTS	SPOP	0.9788	More...
P13284	Gamma-interferon-inducible lysosomal thiol reductase	DEG_SPOP_SBC_1	238:242	PSSTS	SPOP	0.8439	More...
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SPOP_SBC_1	621:625	PSSTS	SPOP	0.9072	More...
P35227	Polycomb group RING finger protein 2	DEG_SPOP_SBC_1	324:328	PSSTS	SPOP	0.9906	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1594:1598	PSSTS	SPOP	0.9808	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2288:2292	PSSTS	SPOP	0.8032	More...
Q03468	DNA excision repair protein ERCC-6	DEG_SPOP_SBC_1	1344:1348	PSSTS	SPOP	0.9734	More...
Q13111	Chromatin assembly factor 1 subunit A	DEG_SPOP_SBC_1	290:294	PSSTS	SPOP	0.8679	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	1236:1240	PSSTS	SPOP	0.7216	More...
Q53GS7	mRNA export factor GLE1	DEG_SPOP_SBC_1	71:75	PSSTS	SPOP	0.962	More...
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_SPOP_SBC_1	159:163	PSSTS	SPOP	0.9843	More...
Q5T7W7	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2	DEG_SPOP_SBC_1	2:6	PSSTS	SPOP	0.938	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	259:263	PSSTS	SPOP	0.9983	More...
Q5VU43	Myomegalin	DEG_SPOP_SBC_1	1658:1662	PSSTS	SPOP	0.9862	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	618:622	PSSTS	SPOP	0.8473	More...
Q86YZ3	Hornerin	DEG_SPOP_SBC_1	2832:2836	PSSTS	SPOP	0.9572	More...
Q8IZA3	Histone H1.8	DEG_SPOP_SBC_1	12:16	PSSTS	SPOP	0.9853	More...
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	DEG_SPOP_SBC_1	3304:3308	PSSTS	SPOP	0.9875	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	895:899	PSSTS	SPOP	0.9869	More...
Q8N554	Zinc finger protein 276	DEG_SPOP_SBC_1	344:348	PSSTS	SPOP	0.8492	More...
Q8N6C5	Immunoglobulin superfamily member 1	DEG_SPOP_SBC_1	1321:1325	PSSTS	SPOP	0.9927	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2724:2728	PSSTS	SPOP	0.8319	More...
Q96HA7	Tonsoku-like protein	DEG_SPOP_SBC_1	859:863	PSSTS	SPOP	0.9959	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	2134:2138	PSSTS	SPOP	0.9955	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	808:812	PSSTS	SPOP	0.9968	More...
Q9BUF7	Protein crumbs homolog 3	DEG_SPOP_SBC_1	41:45	PSSTS	SPOP	0.5098	More...
Q9NXR1	Nuclear distribution protein nudE homolog 1	DEG_SPOP_SBC_1	305:309	PSSTS	SPOP	0.9986	More...
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	DEG_SPOP_SBC_1	380:384	PSSTS	SPOP	0.9419	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1029:1033	PSSTS	SPOP	0.9878	More...
Q9ULJ8	Neurabin-1	DEG_SPOP_SBC_1	929:933	PSSTS	SPOP	0.988	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	110:114	PSSTS	SPOP	0.9898	More...
Q6EKJ0	General transcription factor II-I repeat domain-containing protein 2B	DEG_SPOP_SBC_1	253:257	PSSTS	SPOP	0.9881	More...
Q86UP8	General transcription factor II-I repeat domain-containing protein 2A	DEG_SPOP_SBC_1	253:257	PSSTS	SPOP	0.9876	More...
Q9P1W3	Calcium permeable stress-gated cation channel 1	DEG_SPOP_SBC_1	730:734	PSSTS	SPOP	0.8171	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	818:822	PSSTS	SPOP	0.974	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	835:839	PSSTS	SPOP	0.9702	More...
Q96MY1	Nucleolar protein 4-like	DEG_SPOP_SBC_1	385:389	PSSTS	SPOP	0.7821	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	343:347	PSSTS	SPOP	0.9983	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	2031:2035	PSSTS	SPOP	0.7612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTS

Degron related mutations and impact score

Drug responses associated with PTPRD mutations

All proteins holding degron of PSSTS