ERGR - Ethanol-Related Gene Resource

Dataset Description

Dataset Name: 16618939

Species: Mouse

No. of Genes: 71

Tissue: Whole brain

Phenotype: Alcohol preference

Publication: Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed

Dataset Summary: Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.

Gene list of this dataset (71 genes)

GeneID Symbol Name Genetic location Original ID1 Original ID2
12010 B2m beta-2 microglobulin 2 F1-F3|2 69.0 cM B2m
17159 Man2b1 mannosidase 2, alpha B1 8 C2|8 37.0 cM Man2b1
68721 1110032A03Rik RIKEN cDNA 1110032A03 gene 9 B 1110032A03Rik
1456111_at
399548 Scn4b sodium channel, type IV, beta 9 A5.2 Scn4b
102060 Gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 8 C3 Gadd45gip1
414077 BC056474 cDNA sequence BC056474 8 C3 BC056474
13589 Mapre1 microtubule-associated protein, RP/EB family, member 1 2 H1|2 84.0 cM Mapre1
21672 Prdx2 peroxiredoxin 2 8 C3|8 36.0 cM Prdx2
66155 Ufc1 ubiquitin-fold modifier conjugating enzyme 1 1 H3|1 93.0 cM 1110021H02Rik
Orc61
1420287_at
56405 Dusp14 dual specificity phosphatase 14 11 C|11 48.0 cM Dusp14
27984 Efhd2 EF hand domain containing 2 4 E1|4 69.8 cM Efhd2
1416947_s_at
65247 Asb1 ankyrin repeat and SOCS box-containing protein 1 1 D|1 57.0 cM Asb1
68272 Rbm28 RNA binding motif protein 28 6 A3.3 Rbm28
216853 Wdr79 WD repeat domain 79 11 B3 BC021790
71310 Tbc1d9 TBC1 domain family, member 9 8 C3 4933431N12Rik
68365 Rab14 RAB14, member RAS oncogene family 2 B Rab14
19175 Psmb6 proteasome (prosome, macropain) subunit, beta type 6 11 B3|11 39.0 cM Psmb6
219151 Scara3 scavenger receptor class A, member 3 14 D1 Scara3
80509 Med8 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) 4 D1 Med8
18754 Prkce protein kinase C, epsilon 17 E4 Prkce
102614 Rpp25 ribonuclease P 25 subunit (human) 9 B Rpp25
16562 Kif1c kinesin family member 1C 11 B3 Kif1c
18762 Prkcz protein kinase C, zeta 4 E2|4 83.0 cM Prkcz
140559 Igsf8 immunoglobulin superfamily, member 8 1 H3|1 94.2 cM Igsf8
12847 Copa coatomer protein complex subunit alpha 1 H3|1 93.5 cM Copa
12260 C1qb complement component 1, q subcomponent, beta polypeptide 4 D3|4 66.1 cM C1qb
269424 Phf17 PHD finger protein 17 3 B Phf17
11757 Prdx3 peroxiredoxin 3 19 D3|19 50.0 cM 1416292_at
98660 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1 H3|1 94.2 cM Atp1a2
18005 Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 1 H6|1 103.0 cM Nek2
29858 Pmm1 phosphomannomutase 1 15 E1 Pmm1
53421 Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 6 D1 Sec61a1
13030 Ctsb cathepsin B 14 D1|14 28.0 cM Ctsb
68939 Rasl11b RAS-like, family 11, member B 5 D Rasl11b
53972 Ngef neuronal guanine nucleotide exchange factor 1 D|1 54.0 cM Ngef
231440 9130213B05Rik RIKEN cDNA 9130213B05 gene 5 E2 9130213B05Rik
67181 Dullard Dullard homolog (Xenopus laevis) 11 B4 Dullard
68666 Svop SV2 related protein 5 F 1110030H18Rik
232879 Zbtb45 zinc finger and BTB domain containing 45 7 A1 Gm157
100532 Rell1 RELT-like 1 5 C3.1 AA536743
22192 Ube2m ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 7 A1|7 4.0 cM Ube2m
20604 Sst somatostatin 16 cen-C3|16 19.0 cM Sst
23908 Hs2st1 heparan sulfate 2-O-sulfotransferase 1 3 H2 Hs2st1
78832 2700078E11Rik RIKEN cDNA 2700078E11 gene 19 D3 2700078E11Rik
21987 Tpd52l1 tumor protein D52-like 1 10 A4-B2 Tpd52l1
56347 Eif3c eukaryotic translation initiation factor 3, subunit C - Eif3s8
66411 Tbcb tubulin folding cofactor B 7 B1 Ckap1
66077 Aurkaip1 aurora kinase A interacting protein 1 4 E2|4 83.0 cM 0610033H09Rik
71566 9030425E11Rik RIKEN cDNA 9030425E11 gene 9 A5.1 9030425E11Rik
68035 Rbm42 RNA binding motif protein 42 7 B1 3100004P22Rik
23948 Mmp17 matrix metallopeptidase 17 5 G1.3|5 72.5 cM Mmp17
26921 Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 - Map4k4
12345 Capzb capping protein (actin filament) muscle Z-line, beta 4 D3|4 66.8 cM Capzb
52174 D4Ertd196e DNA segment, Chr 4, ERATO Doi 196, expressed 4 D2.3|4 65.7 cM D4Ertd196e
11803 Aplp1 amyloid beta (A4) precursor-like protein 1 7 B1|7 8.0 cM Aplp1
51788 H2afz H2A histone family, member Z 3 G3 H2afz
67389 C1qdc2 C1q domain containing 2 4 E2|4 83.0 cM 1110035L05Rik
13135 Dad1 defender against cell death 1 14 C2|14 24.0 cM Dad1
19243 Ptp4a1 protein tyrosine phosphatase 4a1 1 B Ptp4a1
16010 Igfbp4 insulin-like growth factor binding protein 4 11 D Igfbp4
76829 Dok5 docking protein 5 2 H3|2 99.0 cM Dok5
77065 Ints7 integrator complex subunit 7 1 H6 5930412E23Rik
15939 Ier5 immediate early response 5 1 G3|1 81.5 cM Ier5
13007 Csrp1 cysteine and glycine-rich protein 1 1 E4 Csrp1
27379 Tcl1b1 T-cell leukemia/lymphoma 1B, 1 12 E Tcl1b1
12282 Hyou1 hypoxia up-regulated 1 9 B Hyou1
15331 Hmgn2 high mobility group nucleosomal binding domain 2 4 D3|4 62.2 cM Hmgn2
101214 Tra2a transformer 2 alpha homolog (Drosophila) 6 B2.3 1500010G04Rik
17967 Ncam1 neural cell adhesion molecule 1 9 A5.3|9 28.0 cM 1426865_a_at
14688 Gnb1 guanine nucleotide binding protein (G protein), beta 1 4 E2|4 79.4 cM Gnb1
14688 Gnb1 guanine nucleotide binding protein (G protein), beta 1 4 E2|4 79.4 cM 1454696_at

GeneID	Symbol	Name	Genetic location	Original ID1	Original ID2
12010	B2m	beta-2 microglobulin	2 F1-F3\|2 69.0 cM	B2m
17159	Man2b1	mannosidase 2, alpha B1	8 C2\|8 37.0 cM	Man2b1
68721	1110032A03Rik	RIKEN cDNA 1110032A03 gene	9 B	1110032A03Rik
				1456111_at
399548	Scn4b	sodium channel, type IV, beta	9 A5.2	Scn4b
102060	Gadd45gip1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	8 C3	Gadd45gip1
414077	BC056474	cDNA sequence BC056474	8 C3	BC056474
13589	Mapre1	microtubule-associated protein, RP/EB family, member 1	2 H1\|2 84.0 cM	Mapre1
21672	Prdx2	peroxiredoxin 2	8 C3\|8 36.0 cM	Prdx2
66155	Ufc1	ubiquitin-fold modifier conjugating enzyme 1	1 H3\|1 93.0 cM	1110021H02Rik
				Orc61
				1420287_at
56405	Dusp14	dual specificity phosphatase 14	11 C\|11 48.0 cM	Dusp14
27984	Efhd2	EF hand domain containing 2	4 E1\|4 69.8 cM	Efhd2
				1416947_s_at
65247	Asb1	ankyrin repeat and SOCS box-containing protein 1	1 D\|1 57.0 cM	Asb1
68272	Rbm28	RNA binding motif protein 28	6 A3.3	Rbm28
216853	Wdr79	WD repeat domain 79	11 B3	BC021790
71310	Tbc1d9	TBC1 domain family, member 9	8 C3	4933431N12Rik
68365	Rab14	RAB14, member RAS oncogene family	2 B	Rab14
19175	Psmb6	proteasome (prosome, macropain) subunit, beta type 6	11 B3\|11 39.0 cM	Psmb6
219151	Scara3	scavenger receptor class A, member 3	14 D1	Scara3
80509	Med8	mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)	4 D1	Med8
18754	Prkce	protein kinase C, epsilon	17 E4	Prkce
102614	Rpp25	ribonuclease P 25 subunit (human)	9 B	Rpp25
16562	Kif1c	kinesin family member 1C	11 B3	Kif1c
18762	Prkcz	protein kinase C, zeta	4 E2\|4 83.0 cM	Prkcz
140559	Igsf8	immunoglobulin superfamily, member 8	1 H3\|1 94.2 cM	Igsf8
12847	Copa	coatomer protein complex subunit alpha	1 H3\|1 93.5 cM	Copa
12260	C1qb	complement component 1, q subcomponent, beta polypeptide	4 D3\|4 66.1 cM	C1qb
269424	Phf17	PHD finger protein 17	3 B	Phf17
11757	Prdx3	peroxiredoxin 3	19 D3\|19 50.0 cM	1416292_at
98660	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1 H3\|1 94.2 cM	Atp1a2
18005	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	1 H6\|1 103.0 cM	Nek2
29858	Pmm1	phosphomannomutase 1	15 E1	Pmm1
53421	Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	6 D1	Sec61a1
13030	Ctsb	cathepsin B	14 D1\|14 28.0 cM	Ctsb
68939	Rasl11b	RAS-like, family 11, member B	5 D	Rasl11b
53972	Ngef	neuronal guanine nucleotide exchange factor	1 D\|1 54.0 cM	Ngef
231440	9130213B05Rik	RIKEN cDNA 9130213B05 gene	5 E2	9130213B05Rik
67181	Dullard	Dullard homolog (Xenopus laevis)	11 B4	Dullard
68666	Svop	SV2 related protein	5 F	1110030H18Rik
232879	Zbtb45	zinc finger and BTB domain containing 45	7 A1	Gm157
100532	Rell1	RELT-like 1	5 C3.1	AA536743
22192	Ube2m	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	7 A1\|7 4.0 cM	Ube2m
20604	Sst	somatostatin	16 cen-C3\|16 19.0 cM	Sst
23908	Hs2st1	heparan sulfate 2-O-sulfotransferase 1	3 H2	Hs2st1
78832	2700078E11Rik	RIKEN cDNA 2700078E11 gene	19 D3	2700078E11Rik
21987	Tpd52l1	tumor protein D52-like 1	10 A4-B2	Tpd52l1
56347	Eif3c	eukaryotic translation initiation factor 3, subunit C	-	Eif3s8
66411	Tbcb	tubulin folding cofactor B	7 B1	Ckap1
66077	Aurkaip1	aurora kinase A interacting protein 1	4 E2\|4 83.0 cM	0610033H09Rik
71566	9030425E11Rik	RIKEN cDNA 9030425E11 gene	9 A5.1	9030425E11Rik
68035	Rbm42	RNA binding motif protein 42	7 B1	3100004P22Rik
23948	Mmp17	matrix metallopeptidase 17	5 G1.3\|5 72.5 cM	Mmp17
26921	Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	-	Map4k4
12345	Capzb	capping protein (actin filament) muscle Z-line, beta	4 D3\|4 66.8 cM	Capzb
52174	D4Ertd196e	DNA segment, Chr 4, ERATO Doi 196, expressed	4 D2.3\|4 65.7 cM	D4Ertd196e
11803	Aplp1	amyloid beta (A4) precursor-like protein 1	7 B1\|7 8.0 cM	Aplp1
51788	H2afz	H2A histone family, member Z	3 G3	H2afz
67389	C1qdc2	C1q domain containing 2	4 E2\|4 83.0 cM	1110035L05Rik
13135	Dad1	defender against cell death 1	14 C2\|14 24.0 cM	Dad1
19243	Ptp4a1	protein tyrosine phosphatase 4a1	1 B	Ptp4a1
16010	Igfbp4	insulin-like growth factor binding protein 4	11 D	Igfbp4
76829	Dok5	docking protein 5	2 H3\|2 99.0 cM	Dok5
77065	Ints7	integrator complex subunit 7	1 H6	5930412E23Rik
15939	Ier5	immediate early response 5	1 G3\|1 81.5 cM	Ier5
13007	Csrp1	cysteine and glycine-rich protein 1	1 E4	Csrp1
27379	Tcl1b1	T-cell leukemia/lymphoma 1B, 1	12 E	Tcl1b1
12282	Hyou1	hypoxia up-regulated 1	9 B	Hyou1
15331	Hmgn2	high mobility group nucleosomal binding domain 2	4 D3\|4 62.2 cM	Hmgn2
101214	Tra2a	transformer 2 alpha homolog (Drosophila)	6 B2.3	1500010G04Rik
17967	Ncam1	neural cell adhesion molecule 1	9 A5.3\|9 28.0 cM	1426865_a_at
14688	Gnb1	guanine nucleotide binding protein (G protein), beta 1	4 E2\|4 79.4 cM	Gnb1
14688	Gnb1	guanine nucleotide binding protein (G protein), beta 1	4 E2\|4 79.4 cM	1454696_at