Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
Organism: Hsapiens, Id Type: entrezgene, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene set are listed in this table. For each gene set, the first row lists the gene set name, and corresponding Gene Set ID. The second row lists number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP). Finally, genes in the gene set are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.
microRNA Target----hsa_TGCACTT,MIR-519C,MIR-519B,MIR-519A----DB_ID:677
C=443;O=17;E=3.50;R=4.85;rawP=1.19e-07;adjP=1.76e-05
659 NA 659 ENSG00000204217 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
81839 NA 81839 ENSG00000173218 VANGL1 vang-like 1 (van gogh, Drosophila)
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
4090 NA 4090 ENSG00000113658 SMAD5 SMAD family member 5
5156 NA 5156 ENSG00000134853 PDGFRA platelet-derived growth factor receptor, alpha polypeptide
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
3037 NA 3037 ENSG00000170961 HAS2 hyaluronan synthase 2
1073 NA 1073 ENSG00000165410 CFL2 cofilin 2 (muscle)
64881 NA 64881 ENSG00000197991 PCDH20 protocadherin 20
10746 NA 10746 ENSG00000169967 MAP3K2 mitogen-activated protein kinase kinase kinase 2
8600 NA 8600 ENSG00000120659 TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
8742 NA 8742 ENSG00000239697 TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
3091 NA 3091 ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
3984 NA 3984 ENSG00000106683 LIMK1 LIM domain kinase 1
4134 NA 4134 ENSG00000047849 MAP4 microtubule-associated protein 4
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
9475 NA 9475 ENSG00000134318 ROCK2 Rho-associated, coiled-coil containing protein kinase 2
microRNA Target----hsa_CAGTATT,MIR-200B,MIR-200C,MIR-429----DB_ID:679
C=465;O=16;E=3.68;R=4.35;rawP=1.18e-06;adjP=6.81e-05
387 NA 387 ENSG00000067560 RHOA ras homolog family member A
2335 NA 2335 ENSG00000115414 FN1 fibronectin 1
2104 NA 2104 ENSG00000196482 ESRRG estrogen-related receptor gamma
4035 NA 4035 ENSG00000123384 LRP1 low density lipoprotein receptor-related protein 1
331 NA 331 ENSG00000101966 XIAP X-linked inhibitor of apoptosis
3398 NA 3398 ENSG00000115738 ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
7422 NA 7422 ENSG00000112715 VEGFA vascular endothelial growth factor A
3953 NA 3953 ENSG00000116678 LEPR leptin receptor
1605 NA 1605 ENSG00000173402 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
1073 NA 1073 ENSG00000165410 CFL2 cofilin 2 (muscle)
775 NA 775 ENSG00000151067 CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
2273 NA 2273 ENSG00000022267 FHL1 four and a half LIM domains 1
846 NA 846 ENSG00000036828 CASR calcium-sensing receptor
59272 NA 59272 ENSG00000130234 ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
1843 NA 1843 ENSG00000120129 DUSP1 dual specificity phosphatase 1
1545 NA 1545 ENSG00000138061 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
microRNA Target----hsa_TGCTGCT,MIR-15A,MIR-16,MIR-15B,MIR-195,MIR-424,MIR-497----DB_ID:666
C=593;O=18;E=4.69;R=3.84;rawP=1.53e-06;adjP=6.81e-05
993 NA 993 ENSG00000164045 CDC25A cell division cycle 25 homolog A (S. pombe)
8862 NA 8862 ENSG00000171388 APLN apelin
2104 NA 2104 ENSG00000196482 ESRRG estrogen-related receptor gamma
5166 NA 5166 ENSG00000004799 PDK4 pyruvate dehydrogenase kinase, isozyme 4
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
4090 NA 4090 ENSG00000113658 SMAD5 SMAD family member 5
7422 NA 7422 ENSG00000112715 VEGFA vascular endothelial growth factor A
3037 NA 3037 ENSG00000170961 HAS2 hyaluronan synthase 2
4088 NA 4088 ENSG00000166949 SMAD3 SMAD family member 3
7049 NA 7049 ENSG00000069702 TGFBR3 transforming growth factor, beta receptor III
4775 NA 4775 ENSG00000072736 NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
6532 NA 6532 ENSG00000108576 SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
57060 NA 57060 ENSG00000090097 PCBP4 poly(rC) binding protein 4
4134 NA 4134 ENSG00000047849 MAP4 microtubule-associated protein 4
5292 NA 5292 ENSG00000137193 PIM1 pim-1 oncogene
2101 NA 2101 ENSG00000173153 ESRRA estrogen-related receptor alpha
846 NA 846 ENSG00000036828 CASR calcium-sensing receptor
57154 NA 57154 ENSG00000198742 SMURF1 SMAD specific E3 ubiquitin protein ligase 1
microRNA Target----hsa_TTTTGAG,MIR-373----DB_ID:844
C=222;O=11;E=1.76;R=6.27;rawP=1.84e-06;adjP=6.81e-05
2335 NA 2335 ENSG00000115414 FN1 fibronectin 1
3091 NA 3091 ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
56937 NA 56937 ENSG00000124225 PMEPA1 prostate transmembrane protein, androgen induced 1
3065 NA 3065 ENSG00000116478 HDAC1 histone deacetylase 1
688 NA 688 ENSG00000102554 KLF5 Kruppel-like factor 5 (intestinal)
10891 NA 10891 ENSG00000109819 PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
30819 NA 30819 ENSG00000120049 KCNIP2 Kv channel interacting protein 2
841 NA 841 ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase
1605 NA 1605 ENSG00000173402 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
29843 NA 29843 ENSG00000079387 SENP1 SUMO1/sentrin specific peptidase 1
1073 NA 1073 ENSG00000165410 CFL2 cofilin 2 (muscle)
microRNA Target----hsa_GCACTTT,MIR-17-5P,MIR-20A,MIR-106A,MIR-106B,MIR-20B,MIR-519D----DB_ID:665
C=586;O=17;E=4.63;R=3.67;rawP=5.43e-06;adjP=0.0002
659 NA 659 ENSG00000204217 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
81839 NA 81839 ENSG00000173218 VANGL1 vang-like 1 (van gogh, Drosophila)
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
4090 NA 4090 ENSG00000113658 SMAD5 SMAD family member 5
7422 NA 7422 ENSG00000112715 VEGFA vascular endothelial growth factor A
5156 NA 5156 ENSG00000134853 PDGFRA platelet-derived growth factor receptor, alpha polypeptide
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
3037 NA 3037 ENSG00000170961 HAS2 hyaluronan synthase 2
1073 NA 1073 ENSG00000165410 CFL2 cofilin 2 (muscle)
10746 NA 10746 ENSG00000169967 MAP3K2 mitogen-activated protein kinase kinase kinase 2
595 NA 595 ENSG00000110092 CCND1 cyclin D1
8600 NA 8600 ENSG00000120659 TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
8742 NA 8742 ENSG00000239697 TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
3091 NA 3091 ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
3984 NA 3984 ENSG00000106683 LIMK1 LIM domain kinase 1
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
29843 NA 29843 ENSG00000079387 SENP1 SUMO1/sentrin specific peptidase 1
microRNA Target----hsa_TTTGCAC,MIR-19A,MIR-19B----DB_ID:696
C=511;O=15;E=4.04;R=3.71;rawP=1.69e-05;adjP=0.0004
7471 NA 7471 ENSG00000125084 WNT1 wingless-type MMTV integration site family, member 1
659 NA 659 ENSG00000204217 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
1490 NA 1490 ENSG00000118523 CTGF connective tissue growth factor
775 NA 775 ENSG00000151067 CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
56937 NA 56937 ENSG00000124225 PMEPA1 prostate transmembrane protein, androgen induced 1
147381 NA 147381 ENSG00000141668 CBLN2 cerebellin 2 precursor
23365 NA 23365 ENSG00000196914 ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
4090 NA 4090 ENSG00000113658 SMAD5 SMAD family member 5
3337 NA 3337 ENSG00000132002 DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
2099 NA 2099 ENSG00000091831 ESR1 estrogen receptor 1
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
1605 NA 1605 ENSG00000173402 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
55107 NA 55107 ENSG00000131620 ANO1 anoctamin 1, calcium activated chloride channel
10425 NA 10425 ENSG00000177479 ARIH2 ariadne homolog 2 (Drosophila)
388 NA 388 ENSG00000143878 RHOB ras homolog family member B
microRNA Target----hsa_ATAAGCT,MIR-21----DB_ID:814
C=113;O=7;E=0.89;R=7.83;rawP=3.42e-05;adjP=0.0006
993 NA 993 ENSG00000164045 CDC25A cell division cycle 25 homolog A (S. pombe)
55193 NA 55193 ENSG00000163939 PBRM1 polybromo 1
7045 NA 7045 ENSG00000120708 TGFBI transforming growth factor, beta-induced, 68kDa
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
388 NA 388 ENSG00000143878 RHOB ras homolog family member B
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
microRNA Target----hsa_AAAGACA,MIR-511----DB_ID:813
C=199;O=9;E=1.57;R=5.72;rawP=3.28e-05;adjP=0.0006
595 NA 595 ENSG00000110092 CCND1 cyclin D1
10746 NA 10746 ENSG00000169967 MAP3K2 mitogen-activated protein kinase kinase kinase 2
2335 NA 2335 ENSG00000115414 FN1 fibronectin 1
1636 NA 1636 ENSG00000159640 ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
56937 NA 56937 ENSG00000124225 PMEPA1 prostate transmembrane protein, androgen induced 1
2104 NA 2104 ENSG00000196482 ESRRG estrogen-related receptor gamma
10891 NA 10891 ENSG00000109819 PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
284273 NA 284273 ENSG00000180011 ZADH2 zinc binding alcohol dehydrogenase domain containing 2
3037 NA 3037 ENSG00000170961 HAS2 hyaluronan synthase 2
microRNA Target----hsa_TGAATGT,MIR-181A,MIR-181B,MIR-181C,MIR-181D----DB_ID:669
C=479;O=13;E=3.79;R=3.43;rawP=0.0001;adjP=0.0012
26585 NA 26585 ENSG00000166923 GREM1 gremlin 1
8600 NA 8600 ENSG00000120659 TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
659 NA 659 ENSG00000204217 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
5166 NA 5166 ENSG00000004799 PDK4 pyruvate dehydrogenase kinase, isozyme 4
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
3552 NA 3552 ENSG00000115008 IL1A interleukin 1, alpha
7045 NA 7045 ENSG00000120708 TGFBI transforming growth factor, beta-induced, 68kDa
2353 NA 2353 ENSG00000170345 FOS FBJ murine osteosarcoma viral oncogene homolog
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
2099 NA 2099 ENSG00000091831 ESR1 estrogen receptor 1
5156 NA 5156 ENSG00000134853 PDGFRA platelet-derived growth factor receptor, alpha polypeptide
29843 NA 29843 ENSG00000079387 SENP1 SUMO1/sentrin specific peptidase 1
55107 NA 55107 ENSG00000131620 ANO1 anoctamin 1, calcium activated chloride channel
microRNA Target----hsa_ACATATC,MIR-190----DB_ID:806
C=60;O=5;E=0.47;R=10.54;rawP=0.0001;adjP=0.0012
10194 NA 10194 ENSG00000179981 TSHZ1 teashirt zinc finger homeobox 1
1027 NA 1027 ENSG00000111276 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
3082 NA 3082 ENSG00000019991 HGF hepatocyte growth factor (hepapoietin A; scatter factor)
1605 NA 1605 ENSG00000173402 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
3037 NA 3037 ENSG00000170961 HAS2 hyaluronan synthase 2


')