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Dataset Description
  • Dataset Name: 17517326
  • Species: Rat
  • Method: Microarray
  • No. of Genes: 77
  • Tissue: Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
  • Phenotype: Alcohol-preferring, alcohol-nonpreferring
  • Publication: Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
  • Dataset Summary: The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

    Gene list of this dataset (77 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    308923Ahi1Abelson helper integration site 11p12Ahi1 
    300850Gsta4glutathione S-transferase, alpha 48q31Gsta4 
    60442Lin7clin-7 homolog C (C. elegans)3q33Lin7c 
    83789Rps2ribosomal protein S210q12Rps2 
    24737RT1-Aw2RT1 class Ib, locus Aw220p12RT1-Aw2 
    308993Sephs2selenophosphate synthetase 21q36Sephs2 
    361813Stk38serine/threonine kinase 3820p12Stk38 
    497770Scn3asodium channel, voltage-gated, type III, alpha3q21Scn3a 
    114507Slc5a3solute carrier family 5 (inositol transporters), member 311q11Slc5a3 
    498549Akap11A kinase (PRKA) anchor protein 1115q11Akap11 
    25095Ampd3adenosine monophosphate deaminase 31q35-q36Ampd3 
    24248Catcatalase3q32-q34Cat 
    25211Lyzlysozyme7q22Lyz 
    24644Pgk1phosphoglycerate kinase 1Xq31Pgk1 
    29672Psma5proteasome (prosome, macropain) subunit, alpha type 52q34Psma5 
    309622RT1-BbRT1 class II, locus Bb20p12RT1-Bb 
    25675Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase2q12Hmgcr 
    58835Phgdh3-phosphoglycerate dehydrogenase2q34Phgdh 
    308923Ahi1Abelson helper integration site 11p12Ahi1 
    64462Csnk1dcasein kinase 1, delta10q32.3Csnk1d 
    25402Casp3caspase 3, apoptosis related cysteine protease16q11Casp3 
    685781Ddr2discoidin domain receptor family, member 213q24Ddr2 
    79114Fgfr1Fibroblast growth factor receptor 116q12.4Fgfr1 
    25661Fn1fibronectin 19q33Fn1 
    300850Gsta4glutathione S-transferase, alpha 48q31Gsta4 
    59319Nyw1ischemia related factor NYW-13q24Nyw1 
    25589Kdrkinase insert domain protein receptor-Kdr 
    60442Lin7clin-7 homolog C (C. elegans)3q33Lin7c 
    24914Loxlysyl oxidase18q11Lox 
    29432Pak2p21 (CDKN1A)-activated kinase 211q22Pak2 
    83789Rps2ribosomal protein S210q12Rps2 
    24737RT1-Aw2RT1 class Ib, locus Aw220p12RT1-Aw2 
    308993Sephs2selenophosphate synthetase 21q36Sephs2 
    497770Scn3asodium channel, voltage-gated, type III, alpha3q21Scn3a 
    60423Slc28a2solute carrier family 28 (sodium-coupled nucleoside transporter), member 23q35Slc28a2 
    114507Slc5a3solute carrier family 5 (inositol transporters), member 311q11Slc5a3 
    114858Shc3src homology 2 domain-containing transforming protein C317p14Shc3 
    25123Taglntransgelin8q24Tagln 
    81643Atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase9q33Atic 
    25288Acsl1acyl-CoA synthetase long-chain family member 116q11Acsl1 
    295365Amigo1adhesion molecule with Ig like domain 12q34Amigo 
    114901Argbp2Arg/Abl-interacting protein ArgBP216q11Argbp2 
    25612Asnsasparagine synthetase-Asns 
    83526Atrnattractin3q36Atrn 
    29619Btg2B-cell translocation gene 2, anti-proliferative-Btg2 
    83465Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)2q34Celsr2 
    25145Cd24CD24 antigen20q13Cd24 
    24259Chgbchromogranin B3q36Chgb 
    64514Eif2b1eukaryotic translation initiation factor 2B, subunit 1 alpha12q15Eif2b1 
    25319Fth1ferritin heavy chain 11q43Fth1 
    114017Gfm1G elongation factor, mitochondrial 12q31Gfm 
    362418Irak2interleukin-1 receptor-associated kinase 24q42Irak2 
    24534Ldhblactate dehydrogenase B4q44Ldhb 
    155918Lcp2lymphocyte cytosolic protein 210q12Lcp2 
    25211Lyzlysozyme7q22Lyz 
    83834Nrn1neuritin 1-Nrn1 
    266777Nptx1neuronal pentraxin 110q32.3Nptx1 
    114108Pdlim3PDZ and LIM domain 316q11Pdlim3 
    64198Pmpcbpeptidase (mitochondrial processing) beta4q11Pmpcb 
    81740Pcm1pericentriolar material 116q12.1Pcm1 
    24644Pgk1phosphoglycerate kinase 1Xq31Pgk1 
    29562Prps1phosphoribosyl pyrophosphate synthetase 1Xq35Prps1 
    297508Namptnicotinamide phosphoribosyltransferase6q16Pbef1 
    29672Psma5proteasome (prosome, macropain) subunit, alpha type 52q34Psma5 
    24750RT1-N3RT1 class Ib gene, H2-TL-like, grc region (N3)20p12RT1-N3 
    309622RT1-BbRT1 class II, locus Bb20p12RT1-Bb 
    81921Sh3gl3SH3-domain GRB2-like 31q31Sh3gl3 
    301255Spats1spermatogenesis associated, serine-rich 19q12Spats1 
    25541Scp2sterol carrier protein 25q35Scp2 
    25357Thrspthyroid hormone responsive protein1q32Thrsp 
    58835Phgdh3-phosphoglycerate dehydrogenase2q34Phgdh 
    300850Gsta4glutathione S-transferase, alpha 48q31Gsta4 
    83789Rps2ribosomal protein S210q12Rps2 
    497770Scn3asodium channel, voltage-gated, type III, alpha3q21Scn3a 
    114507Slc5a3solute carrier family 5 (inositol transporters), member 311q11Slc5a3 
    24387Gfapglial fibrillary acidic protein10q32.1Gfap 
    24644Pgk1phosphoglycerate kinase 1Xq31Pgk1 
    29672Psma5proteasome (prosome, macropain) subunit, alpha type 52q34Psma5 
    58835Phgdh3-phosphoglycerate dehydrogenase2q34Phgdh 
    316051Azi25-azacytidine induced gene 28q32Azi2 
    308923Ahi1Abelson helper integration site 11p12Ahi1 
    24223B2mbeta-2 microglobulin3q35B2m 
    25661Fn1fibronectin 19q33Fn1 
    300850Gsta4glutathione S-transferase, alpha 48q31Gsta4 
    59073Lxnlatexin2q31Lxn 
    64633Rab5aRAB5A, member RAS oncogene family9q11Rab5a 
    83789Rps2ribosomal protein S210q12Rps2 
    24737RT1-Aw2RT1 class Ib, locus Aw220p12RT1-Aw2 
    308993Sephs2selenophosphate synthetase 21q36Sephs2 
    361813Stk38serine/threonine kinase 3820p12Stk38 
    114507Slc5a3solute carrier family 5 (inositol transporters), member 311q11Slc5a3 
    25123Taglntransgelin8q24Tagln 
    498549Akap11A kinase (PRKA) anchor protein 1115q11Akap11 
    29139Dcndecorin7q13Dcn 
    58844Grb14growth factor receptor bound protein 143q21Grb14 
    116967Magt1magnesium transporter 1Xq31Iag2 
    24644Pgk1phosphoglycerate kinase 1Xq31Pgk1 
    24750RT1-N3RT1 class Ib gene, H2-TL-like, grc region (N3)20p12RT1-N3 
    65047Slit1slit homolog 1 (Drosophila)1q54Slit1 
    58835Phgdh3-phosphoglycerate dehydrogenase2q34Phgdh 
    308923Ahi1Abelson helper integration site 11p12Ahi1 
    25383Apobec1apolipoprotein B editing complex 14q42Apobec1 
    25661Fn1fibronectin 19q33Fn1 
    300850Gsta4glutathione S-transferase, alpha 48q31Gsta4 
    60442Lin7clin-7 homolog C (C. elegans)3q33Lin7c 
    25520Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit7q36Prkag1 
    117042Rpl6ribosomal protein L612q16Rpl6 
    83789Rps2ribosomal protein S210q12Rps2 
    24737RT1-Aw2RT1 class Ib, locus Aw220p12RT1-Aw2 
    308993Sephs2selenophosphate synthetase 21q36Sephs2 
    497770Scn3asodium channel, voltage-gated, type III, alpha3q21Scn3a 
    114507Slc5a3solute carrier family 5 (inositol transporters), member 311q11Slc5a3 
    114858Shc3src homology 2 domain-containing transforming protein C317p14Shc3 
    171026Akap5A kinase (PRKA) anchor protein 56q24Akap5 
    24192Akr1b1aldo-keto reductase family 1, member B1 (aldose reductase)4q22Akr1b4 
    24179Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)19q12Agt 
    25612Asnsasparagine synthetase-Asns 
    25420Cryabcrystallin, alpha B8q23Cryab 
    60460Hspa2heat shock protein 26q24Hspa2 
    24587Nefhneurofilament, heavy polypeptide14q21Nefh 
    24644Pgk1phosphoglycerate kinase 1Xq31Pgk1 
    29672Psma5proteasome (prosome, macropain) subunit, alpha type 52q34Psma5 
    25165Zfp386zinc finger protein 386 (Kruppel-like)6q33Znf386