Gene Set: 160 by Lewis et al.


     Gene set description
  • Name: 160 by Lewis et al.
  • Method: Gene ranking using optimal weight matrix
  • Number of genes: 160
  • Reference: Sun et al. (2009) Bioinformatics: accepted with minor revision
  • Summary: This dataset is generated by a multi-dimensional evidence-based gene prioritization approach. We performed exhaustive search in a weight-matrix space to find the optimal weight matrix in order to combine four categories of data (association, linkage, expression, and literature). 160 genes are prioritized using the meta-analysis results in Lewis et al. (2003). 

  • We collected schizophrenia related miRNAs, brain expressed miRNAs and non-brain expressed miRNAs from miRNA expression publications. Specifically, we chose 18 miRNAs which have been identified differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray by two researches (Perkins et al. 2007 and Beveridge et al. 2008) respectively. We then used TargetScan (Version 4.2, http://www.targetscan.org/vert_42/) to predict miRNA targets in the GR_WM genes, as shown by the figure.
Target pairs between schizophrenia related miRNAs and schizophrenia candidate genes. Click to see large figure.
     Gene List

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Sort by   Gene ID   Symbol    Full Name   Location 

Gene ID Symbol Official Full Name Location
260425MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 31p12-p11.2
2944GSTM1glutathione S-transferase mu 11p13.3
22854NTNG1netrin G11p13.3
2730GCLMglutamate-cysteine ligase, modifier subunit1p22.1
2899GRIK3glutamate receptor, ionotropic, kainate 31p34-p33
4524MTHFR5,10-methylenetetrahydrofolate reductase (NADPH)1p36.3
2703GJA8gap junction protein, alpha 8, 50kDa1q21.1
23208SYT11synaptotagmin XI1q21.2
3782KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 31q21.3
5999RGS4regulator of G-protein signaling 41q23.3
5321PLA2G4Aphospholipase A2, group IVA (cytosolic, calcium-dependent)1q25
3586IL10interleukin 101q31-q32
1116CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)1q32.1
5362PLXNA2plexin A21q32.2
7257TSNAXtranslin-associated factor X1q42.1
27185DISC1disrupted in schizophrenia 11q42.1
5305PIP4K2Aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha10p12.2
1103CHATcholine acetyltransferase10q11.2
2894GRID1glutamate receptor, ionotropic, delta 110q22
355FASFas (TNF receptor superfamily, member 6)10q24.1
627BDNFbrain-derived neurotrophic factor11p13
6506SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 211p13-p12
7166TPH1tryptophan hydroxylase 111p15.3-p14
1815DRD4dopamine receptor D411p15.5
7054THtyrosine hydroxylase11p15.5
2893GRIA4glutamate receptor, ionotrophic, AMPA 411q22
3606IL18interleukin 18 (interferon-gamma-inducing factor)11q22.2-q22.3
2900GRIK4glutamate receptor, ionotropic, kainate 411q22.3
486FXYD2FXYD domain containing ion transport regulator 211q23
1813DRD2dopamine receptor D211q23
3359HTR3A5-hydroxytryptamine (serotonin) receptor 3A11q23.1
53826FXYD6FXYD domain containing ion transport regulator 611q23.3
4900NRGNneurogranin (protein kinase C substrate, RC3)11q24
2904GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B12p12
4908NTF3neurotrophin 312p13
2065ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)12q13
1610DAOD-amino-acid oxidase12q24
4842NOS1nitric oxide synthase 1 (neuronal)12q24.2-q24.31
3356HTR2A5-hydroxytryptamine (serotonin) receptor 2A13q14-q21
3843IPO5importin 513q32.2
267012DAOAD-amino acid oxidase activator13q33.2|13q34
64067NPAS3neuronal PAS domain protein 314q12-q13
1113CHGAchromogranin A (parathyroid secretory protein 1)14q32
207AKT1v-akt murine thymoma viral oncogene homolog 114q32.32|14q32.32
89832CHRFAM7ACHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion15q13.1
1139CHRNA7cholinergic receptor, nicotinic, alpha 715q14
1544CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 215q24.1
8128ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 215q26
3240HPhaptoglobin16q22.1
63826SRRserine racemase17p13
7157TP53tumor protein p5317p13.1
6532SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 417q11.1-q12
753C18orf1chromosome 18 open reading frame 118p11.2
5289PIK3C3phosphoinositide-3-kinase, class 318q12.3
718C3complement component 319p13.3-p13.2
9253NUMBLnumb homolog (Drosophila)-like19q13.13-q13.2
348APOEapolipoprotein E19q13.2
57142RTN4reticulon 42p16.3
8807IL18RAPinterleukin 18 receptor accessory protein2q12
8809IL18R1interleukin 18 receptor 12q12
8685MARCOmacrophage receptor with collagenous structure2q12-q13
4867NPHP1nephronophthisis 1 (juvenile)2q13
3552IL1Ainterleukin 1, alpha2q14
3553IL1Binterleukin 1, beta2q14
3557IL1RNinterleukin 1 receptor antagonist2q14.2
4929NR4A2nuclear receptor subfamily 4, group A, member 22q22-q23
2571GAD1glutamate decarboxylase 1 (brain, 67kDa)2q31
2066ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)2q33.3-q34
1114CHGBchromogranin B (secretogranin 1)20pter-p12
2937GSSglutathione synthetase20q11.2
10215OLIG2oligodendrocyte lineage transcription factor 221q22.11
27037TRMT2ATRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)22q11.1-22q13|22q11.21
54584GNB1Lguanine nucleotide binding protein (G protein), beta polypeptide 1-like22q11.2
421ARVCFarmadillo repeat gene deletes in velocardiofacial syndrome22q11.21
5625PRODHproline dehydrogenase (oxidase) 122q11.21
5902RANBP1RAN binding protein 122q11.21
6899TBX1T-box 122q11.21
7122CLDN5claudin 522q11.21
7353UFD1Lubiquitin fusion degradation 1 like (yeast)22q11.21
9342SNAP29synaptosomal-associated protein, 29kDa22q11.21
9993DGCR2DiGeorge syndrome critical region gene 222q11.21
29801ZDHHC8zinc finger, DHHC-type containing 822q11.21
65078RTN4Rreticulon 4 receptor22q11.21
1312COMTcatechol-O-methyltransferase22q11.21-q11.23|22q11.21
8214DGCR6DiGeorge syndrome critical region gene 622q11.21|22q11
7494XBP1X-box binding protein 122q12.1|22q12
7533YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide22q12.3
1439CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)22q13.1
6663SOX10SRY (sex determining region Y)-box 1022q13.1
8398PLA2G6phospholipase A2, group VI (cytosolic, calcium-independent)22q13.1
9145SYNGR1synaptogyrin 122q13.1
9463PICK1protein interacting with PRKCA 122q13.1
2847MCHR1melanin-concentrating hormone receptor 122q13.2
23209MLC1megalencephalic leukoencephalopathy with subcortical cysts 122q13.33
9223MAGI1membrane associated guanylate kinase, WW and PDZ domain containing 13p14.1
3269HRH1histamine receptor H13p25
6854SYN2synapsin II3p25
10752CHL1cell adhesion molecule with homology to L1CAM (close homolog of L1)3p26.1
2917GRM7glutamate receptor, metabotropic 73p26.1-p25.1
1814DRD3dopamine receptor D33q13.3

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