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Organism: Hsapiens, Id Type: entrezgene, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2 The results for each enriched gene set are listed in this table. For each gene set, the first row lists the gene set name, and corresponding Gene Set ID. The second row lists number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP). Finally, genes in the gene set are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively. | |||||
| drug----nitric oxide----DB_ID:PA450635 | |||||
| C=131;O=31;E=1.04;R=29.93;rawP=9.36e-37;adjP=2.76e-34 | |||||
| 7124 | NA | 7124 | ENSG00000232810 | TNF | tumor necrosis factor |
| 384 | NA | 384 | ENSG00000081181 | ARG2 | arginase, type II |
| 8862 | NA | 8862 | ENSG00000171388 | APLN | apelin |
| 1636 | NA | 1636 | ENSG00000159640 | ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
| 3791 | NA | 3791 | ENSG00000128052 | KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) |
| 1906 | NA | 1906 | ENSG00000078401 | EDN1 | endothelin 1 |
| 6648 | NA | 6648 | ENSG00000112096 | SOD2 | superoxide dismutase 2, mitochondrial |
| 4842 | NA | 4842 | ENSG00000089250 | NOS1 | nitric oxide synthase 1 (neuronal) |
| 857 | NA | 857 | ENSG00000105974 | CAV1 | caveolin 1, caveolae protein, 22kDa |
| 2977 | NA | 2977 | ENSG00000152402 | GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 |
| 7422 | NA | 7422 | ENSG00000112715 | VEGFA | vascular endothelial growth factor A |
| 3162 | NA | 3162 | ENSG00000100292 | HMOX1 | heme oxygenase (decycling) 1 |
| 5743 | NA | 5743 | ENSG00000073756 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| 185 | NA | 185 | ENSG00000144891 | AGTR1 | angiotensin II receptor, type 1 |
| 1535 | NA | 1535 | ENSG00000051523 | CYBA | cytochrome b-245, alpha polypeptide |
| 3091 | NA | 3091 | ENSG00000100644 | HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
| 2983 | NA | 2983 | ENSG00000061918 | GUCY1B3 | guanylate cyclase 1, soluble, beta 3 |
| 5740 | NA | 5740 | ENSG00000124212 | PTGIS | prostaglandin I2 (prostacyclin) synthase |
| 7432 | NA | 7432 | ENSG00000146469 | VIP | vasoactive intestinal peptide |
| 2643 | NA | 2643 | ENSG00000131979 | GCH1 | GTP cyclohydrolase 1 |
| 5592 | NA | 5592 | ENSG00000185532 | PRKG1 | protein kinase, cGMP-dependent, type I |
| 5054 | NA | 5054 | ENSG00000106366 | SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| 7412 | NA | 7412 | ENSG00000162692 | VCAM1 | vascular cell adhesion molecule 1 |
| 1910 | NA | 1910 | ENSG00000136160 | EDNRB | endothelin receptor type B |
| 6915 | NA | 6915 | ENSG00000006638 | TBXA2R | thromboxane A2 receptor |
| 59272 | NA | 59272 | ENSG00000130234 | ACE2 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 |
| 2982 | NA | 2982 | ENSG00000164116 | GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 |
| 4843 | NA | 4843 | ENSG00000007171 | NOS2 | nitric oxide synthase 2, inducible |
| 50507 | NA | 50507 | ENSG00000086991 | NOX4 | NADPH oxidase 4 |
| 4846 | NA | 4846 | ENSG00000164867 | NOS3 | nitric oxide synthase 3 (endothelial cell) |
| 7498 | NA | 7498 | ENSG00000158125 | XDH | xanthine dehydrogenase |
| drug----estradiol----DB_ID:PA449503 | |||||
| C=122;O=24;E=0.96;R=24.88;rawP=1.32e-26;adjP=1.95e-24 | |||||
| 3292 | NA | 3292 | ENSG00000108786 | HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 |
| 1588 | NA | 1588 | ENSG00000137869 | CYP19A1 | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| 7923 | NA | 7923 | ENSG00000204228 | HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 |
| 5617 | NA | 5617 | ENSG00000172179 | PRL | prolactin |
| 2104 | NA | 2104 | ENSG00000196482 | ESRRG | estrogen-related receptor gamma |
| 6462 | NA | 6462 | ENSG00000129214 | SHBG | sex hormone-binding globulin |
| 3028 | NA | 3028 | ENSG00000072506 | HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 |
| 3294 | NA | 3294 | ENSG00000086696 | HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 |
| 51478 | NA | 51478 | ENSG00000132196 | HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 |
| 3295 | NA | 3295 | ENSG00000133835 | HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 |
| 2100 | NA | 2100 | ENSG00000140009 | ESR2 | estrogen receptor 2 (ER beta) |
| 7422 | NA | 7422 | ENSG00000112715 | VEGFA | vascular endothelial growth factor A |
| 2353 | NA | 2353 | ENSG00000170345 | FOS | FBJ murine osteosarcoma viral oncogene homolog |
| 3953 | NA | 3953 | ENSG00000116678 | LEPR | leptin receptor |
| 6714 | NA | 6714 | ENSG00000197122 | SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| 2103 | NA | 2103 | ENSG00000119715 | ESRRB | estrogen-related receptor beta |
| 595 | NA | 595 | ENSG00000110092 | CCND1 | cyclin D1 |
| 3293 | NA | 3293 | ENSG00000130948 | HSD17B3 | hydroxysteroid (17-beta) dehydrogenase 3 |
| 3952 | NA | 3952 | ENSG00000174697 | LEP | leptin |
| 2852 | NA | 2852 | ENSG00000164850 | GPER | G protein-coupled estrogen receptor 1 |
| 2101 | NA | 2101 | ENSG00000173153 | ESRRA | estrogen-related receptor alpha |
| 2099 | NA | 2099 | ENSG00000091831 | ESR1 | estrogen receptor 1 |
| 51144 | NA | 51144 | ENSG00000149084 | HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 |
| 1545 | NA | 1545 | ENSG00000138061 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| drug----collagenase----DB_ID:PA449107 | |||||
| C=104;O=20;E=0.82;R=24.32;rawP=3.65e-22;adjP=3.59e-20 | |||||
| 7040 | NA | 7040 | ENSG00000105329 | TGFB1 | transforming growth factor, beta 1 |
| 7124 | NA | 7124 | ENSG00000232810 | TNF | tumor necrosis factor |
| 4318 | NA | 4318 | ENSG00000100985 | MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
| 2335 | NA | 2335 | ENSG00000115414 | FN1 | fibronectin 1 |
| 6275 | NA | 6275 | ENSG00000196154 | S100A4 | S100 calcium binding protein A4 |
| 1906 | NA | 1906 | ENSG00000078401 | EDN1 | endothelin 1 |
| 4035 | NA | 4035 | ENSG00000123384 | LRP1 | low density lipoprotein receptor-related protein 1 |
| 4312 | NA | 4312 | ENSG00000196611 | MMP1 | matrix metallopeptidase 1 (interstitial collagenase) |
| 7422 | NA | 7422 | ENSG00000112715 | VEGFA | vascular endothelial growth factor A |
| 2353 | NA | 2353 | ENSG00000170345 | FOS | FBJ murine osteosarcoma viral oncogene homolog |
| 7057 | NA | 7057 | ENSG00000137801 | THBS1 | thrombospondin 1 |
| 6696 | NA | 6696 | ENSG00000118785 | SPP1 | secreted phosphoprotein 1 |
| 5743 | NA | 5743 | ENSG00000073756 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| 8600 | NA | 8600 | ENSG00000120659 | TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 |
| 4314 | NA | 4314 | ENSG00000149968 | MMP3 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| 7076 | NA | 7076 | ENSG00000102265 | TIMP1 | TIMP metallopeptidase inhibitor 1 |
| 4313 | NA | 4313 | ENSG00000087245 | MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
| 6387 | NA | 6387 | ENSG00000107562 | CXCL12 | chemokine (C-X-C motif) ligand 12 |
| 960 | NA | 960 | ENSG00000026508 | CD44 | CD44 molecule (Indian blood group) |
| 5594 | NA | 5594 | ENSG00000100030 | MAPK1 | mitogen-activated protein kinase 1 |
| drug----dinoprostone----DB_ID:PA449345 | |||||
| C=61;O=16;E=0.48;R=33.17;rawP=2.41e-20;adjP=1.78e-18 | |||||
| 1051 | NA | 1051 | ENSG00000172216 | CEBPB | CCAAT/enhancer binding protein (C/EBP), beta |
| 7124 | NA | 7124 | ENSG00000232810 | TNF | tumor necrosis factor |
| 5743 | NA | 5743 | ENSG00000073756 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| 1588 | NA | 1588 | ENSG00000137869 | CYP19A1 | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| 8600 | NA | 8600 | ENSG00000120659 | TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 |
| 1236 | NA | 1236 | ENSG00000126353 | CCR7 | chemokine (C-C motif) receptor 7 |
| 3569 | NA | 3569 | ENSG00000136244 | IL6 | interleukin 6 (interferon, beta 2) |
| 4312 | NA | 4312 | ENSG00000196611 | MMP1 | matrix metallopeptidase 1 (interstitial collagenase) |
| 4773 | NA | 4773 | ENSG00000101096 | NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
| 6915 | NA | 6915 | ENSG00000006638 | TBXA2R | thromboxane A2 receptor |
| 7422 | NA | 7422 | ENSG00000112715 | VEGFA | vascular endothelial growth factor A |
| 2353 | NA | 2353 | ENSG00000170345 | FOS | FBJ murine osteosarcoma viral oncogene homolog |
| 5594 | NA | 5594 | ENSG00000100030 | MAPK1 | mitogen-activated protein kinase 1 |
| 2150 | NA | 2150 | ENSG00000164251 | F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| 4843 | NA | 4843 | ENSG00000007171 | NOS2 | nitric oxide synthase 2, inducible |
| 1956 | NA | 1956 | ENSG00000146648 | EGFR | epidermal growth factor receptor |
| drug----nitroprusside----DB_ID:PA451406 | |||||
| C=29;O=12;E=0.23;R=52.33;rawP=2.26e-18;adjP=1.33e-16 | |||||
| 1535 | NA | 1535 | ENSG00000051523 | CYBA | cytochrome b-245, alpha polypeptide |
| 1636 | NA | 1636 | ENSG00000159640 | ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
| 2983 | NA | 2983 | ENSG00000061918 | GUCY1B3 | guanylate cyclase 1, soluble, beta 3 |
| 1906 | NA | 1906 | ENSG00000078401 | EDN1 | endothelin 1 |
| 135 | NA | 135 | ENSG00000128271 | ADORA2A | adenosine A2a receptor |
| 5592 | NA | 5592 | ENSG00000185532 | PRKG1 | protein kinase, cGMP-dependent, type I |
| 4842 | NA | 4842 | ENSG00000089250 | NOS1 | nitric oxide synthase 1 (neuronal) |
| 10911 | NA | 10911 | ENSG00000049247 | UTS2 | urotensin 2 |
| 2982 | NA | 2982 | ENSG00000164116 | GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 |
| 4843 | NA | 4843 | ENSG00000007171 | NOS2 | nitric oxide synthase 2, inducible |
| 1909 | NA | 1909 | ENSG00000151617 | EDNRA | endothelin receptor type A |
| 4846 | NA | 4846 | ENSG00000164867 | NOS3 | nitric oxide synthase 3 (endothelial cell) |
| drug----becaplermin----DB_ID:PA164749511 | |||||
| C=29;O=11;E=0.23;R=47.97;rawP=1.96e-16;adjP=9.64e-15 | |||||
| 7040 | NA | 7040 | ENSG00000105329 | TGFB1 | transforming growth factor, beta 1 |
| 5154 | NA | 5154 | ENSG00000197461 | PDGFA | platelet-derived growth factor alpha polypeptide |
| 2335 | NA | 2335 | ENSG00000115414 | FN1 | fibronectin 1 |
| 688 | NA | 688 | ENSG00000102554 | KLF5 | Kruppel-like factor 5 (intestinal) |
| 7422 | NA | 7422 | ENSG00000112715 | VEGFA | vascular endothelial growth factor A |
| 5155 | NA | 5155 | ENSG00000100311 | PDGFB | platelet-derived growth factor beta polypeptide |
| 2150 | NA | 2150 | ENSG00000164251 | F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| 5156 | NA | 5156 | ENSG00000134853 | PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| 3037 | NA | 3037 | ENSG00000170961 | HAS2 | hyaluronan synthase 2 |
| 6714 | NA | 6714 | ENSG00000197122 | SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| 5159 | NA | 5159 | ENSG00000113721 | PDGFRB | platelet-derived growth factor receptor, beta polypeptide |
| drug----progesterone----DB_ID:PA451123 | |||||
| C=136;O=17;E=1.08;R=15.81;rawP=9.76e-16;adjP=4.11e-14 | |||||
| 3292 | NA | 3292 | ENSG00000108786 | HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 |
| 1588 | NA | 1588 | ENSG00000137869 | CYP19A1 | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| 5617 | NA | 5617 | ENSG00000172179 | PRL | prolactin |
| 3294 | NA | 3294 | ENSG00000086696 | HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 |
| 51478 | NA | 51478 | ENSG00000132196 | HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 |
| 857 | NA | 857 | ENSG00000105974 | CAV1 | caveolin 1, caveolae protein, 22kDa |
| 2100 | NA | 2100 | ENSG00000140009 | ESR2 | estrogen receptor 2 (ER beta) |
| 7422 | NA | 7422 | ENSG00000112715 | VEGFA | vascular endothelial growth factor A |
| 1956 | NA | 1956 | ENSG00000146648 | EGFR | epidermal growth factor receptor |
| 595 | NA | 595 | ENSG00000110092 | CCND1 | cyclin D1 |
| 5743 | NA | 5743 | ENSG00000073756 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| 3480 | NA | 3480 | ENSG00000140443 | IGF1R | insulin-like growth factor 1 receptor |
| 3952 | NA | 3952 | ENSG00000174697 | LEP | leptin |
| 2852 | NA | 2852 | ENSG00000164850 | GPER | G protein-coupled estrogen receptor 1 |
| 2099 | NA | 2099 | ENSG00000091831 | ESR1 | estrogen receptor 1 |
| 6715 | NA | 6715 | ENSG00000145545 | SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) |
| 1545 | NA | 1545 | ENSG00000138061 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| drug----estrone----DB_ID:PA449512 | |||||
| C=64;O=13;E=0.51;R=25.69;rawP=3.43e-15;adjP=1.26e-13 | |||||
| 3292 | NA | 3292 | ENSG00000108786 | HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 |
| 1588 | NA | 1588 | ENSG00000137869 | CYP19A1 | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| 3293 | NA | 3293 | ENSG00000130948 | HSD17B3 | hydroxysteroid (17-beta) dehydrogenase 3 |
| 7923 | NA | 7923 | ENSG00000204228 | HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 |
| 6462 | NA | 6462 | ENSG00000129214 | SHBG | sex hormone-binding globulin |
| 3028 | NA | 3028 | ENSG00000072506 | HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 |
| 3294 | NA | 3294 | ENSG00000086696 | HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 |
| 51478 | NA | 51478 | ENSG00000132196 | HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 |
| 3295 | NA | 3295 | ENSG00000133835 | HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 |
| 2100 | NA | 2100 | ENSG00000140009 | ESR2 | estrogen receptor 2 (ER beta) |
| 2099 | NA | 2099 | ENSG00000091831 | ESR1 | estrogen receptor 1 |
| 51144 | NA | 51144 | ENSG00000149084 | HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 |
| 1545 | NA | 1545 | ENSG00000138061 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| drug----testosterone----DB_ID:PA451627 | |||||
| C=99;O=14;E=0.78;R=17.88;rawP=5.93e-14;adjP=1.94e-12 | |||||
| 3292 | NA | 3292 | ENSG00000108786 | HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 |
| 1588 | NA | 1588 | ENSG00000137869 | CYP19A1 | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| 3293 | NA | 3293 | ENSG00000130948 | HSD17B3 | hydroxysteroid (17-beta) dehydrogenase 3 |
| 7923 | NA | 7923 | ENSG00000204228 | HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 |
| 6462 | NA | 6462 | ENSG00000129214 | SHBG | sex hormone-binding globulin |
| 3294 | NA | 3294 | ENSG00000086696 | HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 |
| 8630 | NA | 8630 | ENSG00000025423 | HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) |
| 5054 | NA | 5054 | ENSG00000106366 | SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| 3952 | NA | 3952 | ENSG00000174697 | LEP | leptin |
| 2100 | NA | 2100 | ENSG00000140009 | ESR2 | estrogen receptor 2 (ER beta) |
| 2099 | NA | 2099 | ENSG00000091831 | ESR1 | estrogen receptor 1 |
| 6715 | NA | 6715 | ENSG00000145545 | SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) |
| 51144 | NA | 51144 | ENSG00000149084 | HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 |
| 1545 | NA | 1545 | ENSG00000138061 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| drug----simvastatin----DB_ID:PA451363 | |||||
| C=100;O=14;E=0.79;R=17.71;rawP=6.85e-14;adjP=2.02e-12 | |||||
| 387 | NA | 387 | ENSG00000067560 | RHOA | ras homolog family member A |
| 1490 | NA | 1490 | ENSG00000118523 | CTGF | connective tissue growth factor |
| 5468 | NA | 5468 | ENSG00000132170 | PPARG | peroxisome proliferator-activated receptor gamma |
| 6347 | NA | 6347 | ENSG00000108691 | CCL2 | chemokine (C-C motif) ligand 2 |
| 3569 | NA | 3569 | ENSG00000136244 | IL6 | interleukin 6 (interferon, beta 2) |
| 1906 | NA | 1906 | ENSG00000078401 | EDN1 | endothelin 1 |
| 4312 | NA | 4312 | ENSG00000196611 | MMP1 | matrix metallopeptidase 1 (interstitial collagenase) |
| 348 | NA | 348 | ENSG00000130203 | APOE | apolipoprotein E |
| 7412 | NA | 7412 | ENSG00000162692 | VCAM1 | vascular cell adhesion molecule 1 |
| 5054 | NA | 5054 | ENSG00000106366 | SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| 6093 | NA | 6093 | ENSG00000067900 | ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 |
| 3953 | NA | 3953 | ENSG00000116678 | LEPR | leptin receptor |
| 4846 | NA | 4846 | ENSG00000164867 | NOS3 | nitric oxide synthase 3 (endothelial cell) |
| 3156 | NA | 3156 | ENSG00000113161 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase |