DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 826:830

E3 ligase: SPOP

DEGRON score: 0.8469

ASA_SCORE: 81.78

COIL: 0.9204

CONS_SCORE: 0.2966

DSS_SCORE: 0.4945

HELIX: 0.0318

FCONS_SCORE: 0.6374

RIG_SCORE: 0.5684

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S828L	ACH-000896	Bladder Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	0.7667
p.P826T	DO229056	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	0.7031
p.A827T	DO229013	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.6028
p.A827T	DO229016	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.6028
p.A827T	DO229003	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.6028
p.A827T	DO229005	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.6028
p.V835L	TCGA-78-7220	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	0.1944
p.V835L	DO24409	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	0.1944
p.F821L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	0.1944
p.F821L	NCI-H2087	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1944
p.E819D	TCGA-AX-A1CE	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	0.1389
p.E819D	DO42280	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	0.1389
p.P838S	TCGA-EE-A20F	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	0.1111
p.P838S	DO37961	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	0.1111
p.G838D	SNU-81	large_intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1111
p.A839T	SIDM00650	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	0.0833
p.A839T	NCI-H128	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	0.0833
p.C816W	DO224741	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.0556
p.C816W	DO52542	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 19 of 19 entries

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Drug responses associated with NUP153 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PASSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	418:422	PASSS	SPOP	0.9161	More...
Q8TDY4	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	796:800	PASSS	SPOP	0.9822	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	361:365	PASSS	SPOP	0.9939	More...
Q9C0K0	B-cell lymphoma/leukemia 11B	DEG_SPOP_SBC_1	254:258	PASSS	SPOP	0.9929	More...
Q8IZJ3	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8	DEG_SPOP_SBC_1	1763:1767	PASSS	SPOP	0.8309	More...
Q6IMN6	Caprin-2	DEG_SPOP_SBC_1	747:751	PASSS	SPOP	0.9991	More...
Q8NFJ8	Class E basic helix-loop-helix protein 22	DEG_SPOP_SBC_1	54:58	PASSS	SPOP	0.9164	More...
Q9UFE4	Coiled-coil domain-containing protein 39	DEG_SPOP_SBC_1	912:916	PASSS	SPOP	0.8568	More...
P18850	Cyclic AMP-dependent transcription factor ATF-6 alpha	DEG_SPOP_SBC_1	95:99	PASSS	SPOP	0.978	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	181:185	PASSS	SPOP	0.9721	More...
P46934	E3 ubiquitin-protein ligase NEDD4	DEG_SPOP_SBC_1	735:739	PASSS	SPOP	0.9912	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	104:108	PASSS	SPOP	0.9313	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	168:172	PASSS	SPOP	0.9105	More...
P23769	Endothelial transcription factor GATA-2	DEG_SPOP_SBC_1	193:197	PASSS	SPOP	0.9752	More...
Q96F86	Enhancer of mRNA-decapping protein 3	DEG_SPOP_SBC_1	107:111	PASSS	SPOP	0.9996	More...
O00303	Eukaryotic translation initiation factor 3 subunit F	DEG_SPOP_SBC_1	43:47	PASSS	SPOP	0.9551	More...
Q9UK96	F-box only protein 10	DEG_SPOP_SBC_1	322:326	PASSS	SPOP	0.9634	More...
Q6P3S6	F-box only protein 42	DEG_SPOP_SBC_1	508:512	PASSS	SPOP	0.9901	More...
Q96KN9	Gap junction delta-4 protein	DEG_SPOP_SBC_1	353:357	PASSS	SPOP	0.9456	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	32:36	PASSS	SPOP	0.9463	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1772:1776	PASSS	SPOP	0.9504	More...
Q7Z353	Highly divergent homeobox	DEG_SPOP_SBC_1	113:117	PASSS	SPOP	0.9366	More...
Q9UKV0	Histone deacetylase 9	DEG_SPOP_SBC_1	373:377	PASSS	SPOP	0.9671	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	156:160	PASSS	SPOP	0.5793	More...
Q6NT76	Homeobox-containing protein 1	DEG_SPOP_SBC_1	80:84	PASSS	SPOP	0.9872	More...

Showing 1 to 25 of 88 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASSS

Degron related mutations and impact score

Drug responses associated with NUP153 mutations

All proteins holding degron of PASSS