DegronMD

Uniprot ID: Q9UKV0

Source protein: Histone deacetylase 9

Source gene: HDAC9

Class: DEG_SPOP_SBC_1

Location: 373:377

E3 ligase: SPOP

DEGRON score: 0.9671

ASA_SCORE: 57.06

COIL: 0.8534

CONS_SCORE: 0.3298

DSS_SCORE: 0.6348

HELIX: 0.0502

FCONS_SCORE: 0.9889

RIG_SCORE: 0.526

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L386F	TCGA-AX-A3G3	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	0.1944
p.E387D	TCGA-CN-6021	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	0.0556
p.P382H	TCGA-DA-A1I1	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	0.1944
p.Y371C	TCGA-DD-AAE7	LIHC	TCGA	PASSS	DEG_SPOP_SBC_1	0.2778
p.G369V	TCGA-EE-A2GT	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	0.2222
p.G369V	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	0.2222
p.G369V	NCI-H460	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	0.2222
p.G364C	TCGA-EE-A2MQ	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	0.0833
p.P366S	TCGA-FU-A23L	CESC	TCGA	PASSS	DEG_SPOP_SBC_1	0.1389
p.P366S	TCGA-GF-A6C9	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	0.1389
p.S380G	TCGA-IB-7651	PAAD	TCGA	PASSS	DEG_SPOP_SBC_1	0.25
p.L383V	DO49797	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.1667
p.Q376R	DO227985	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.7329
p.G387E	DO233747	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	0.0556
p.A385T	DO13863	GBM	ICGC	PASSS	DEG_SPOP_SBC_1	0.1111
p.G387V	DO16955	KIRC	ICGC	PASSS	DEG_SPOP_SBC_1	0.0556
p.A366V	DO220851	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	0.1389
p.E375K	DO50297	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	0.7022
p.L383I	DO229213	THCA	ICGC	PASSS	DEG_SPOP_SBC_1	0.1667
p.A366T	DO43186	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	0.1389
p.P376L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	0.7582
p.H381Q	SIDM00640	Mesothelioma	GDSC	PASSS	DEG_SPOP_SBC_1	0.2222
p.H381Q	MSTO-211H	pleura	COSMIC	PASSS	DEG_SPOP_SBC_1	0.2222
p.R365C	ACH-000643	Breast Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	0.1111
p.R365C	HDQ-P1	breast	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1111
p.S374C	ACH-001402	Cervical Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	0.7541
p.S374C	SW756	cervix	COSMIC	PASSS	DEG_SPOP_SBC_1	0.7541
p.R365H	ACH-001490	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	0.1111
p.R365H	COR-L321	NS	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1111
p.H378Q	MSTO-211H	pleura	COSMIC	PASSS	DEG_SPOP_SBC_1	0.3056
p.G374A	JHH-7	liver	COSMIC	PASSS	DEG_SPOP_SBC_1	0.754
p.R365Q	HCC2998	large_intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1111
p.G366V	NCI-H460	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1389
p.H376Q	MSTO-211H	pleura	COSMIC	PASSS	DEG_SPOP_SBC_1	0.7582
p.R378Q	HCC2998	large_intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	0.3056
p.G387A	JHH-7	liver	COSMIC	PASSS	DEG_SPOP_SBC_1	0.0556
p.R385K	MFE-319	endometrium	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1111
p.G371A	JHH-7	liver	COSMIC	PASSS	DEG_SPOP_SBC_1	0.2778
p.S363T	CW-2	large_intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	0.0556
p.H365Q	MSTO-211H	pleura	COSMIC	PASSS	DEG_SPOP_SBC_1	0.1111
p.S378T	CW-2	large_intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	0.3056
p.G364V	NCI-H460	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	0.0833

Drug responses associated with HDAC9 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000404	Skin Cancer	p.P15S (No)	CCLE	Panobinostat	0.0451
ACH-000404	Skin Cancer	p.P15S (No)	CCLE	Sorafenib	8
ACH-000638	Lung Cancer	p.P23T (No)	CCLE	Panobinostat	0.1213
ACH-000638	Lung Cancer	p.P23T (No)	CCLE	Sorafenib	8
ACH-000945	Lung Cancer	p.M34I (No)	CCLE	Panobinostat	0.1457
ACH-000945	Lung Cancer	p.M34I (No)	CCLE	Sorafenib	8
ACH-000974	Endometrial/Uterine Cancer	p.R119H (No)	CCLE	Panobinostat	0.1365
ACH-000974	Endometrial/Uterine Cancer	p.R119H (No)	CCLE	Sorafenib	8
ACH-000564	Myeloma	p.R136S (No)	CCLE	Panobinostat	0.0189
ACH-000564	Myeloma	p.R136S (No)	CCLE	Sorafenib	4.0152
ACH-000985	Colon/Colorectal Cancer	p.R171H (No)	CCLE	Panobinostat	0.0359
ACH-000985	Colon/Colorectal Cancer	p.R171H (No)	CCLE	Sorafenib	8
ACH-000899	Skin Cancer	p.P142S (No)	CCLE	Panobinostat	0.0953
ACH-000899	Skin Cancer	p.P142S (No)	CCLE	Sorafenib	8
ACH-000019	Breast Cancer	p.H182R (No)	CCLE	Sorafenib	8
ACH-000869	Lung Cancer	p.P221R (No)	CCLE	Panobinostat	0.0588
ACH-000869	Lung Cancer	p.P221R (No)	CCLE	Sorafenib	7.9219
ACH-000448	Lung Cancer	p.L310I (No)	CCLE	Panobinostat	0.0699
ACH-000448	Lung Cancer	p.L310I (No)	CCLE	Sorafenib	8
ACH-000463	Lung Cancer	p.G366V (Yes)	CCLE	Panobinostat	0.0987
ACH-000463	Lung Cancer	p.G366V (Yes)	CCLE	Sorafenib	8
ACH-000335	Lung Cancer	p.H378Q (Yes)	CCLE	Panobinostat	0.0737
ACH-000335	Lung Cancer	p.H378Q (Yes)	CCLE	Sorafenib	6.9818
ACH-000848	Liver Cancer	p.G415A (No)	CCLE	Panobinostat	0.0567
ACH-000848	Liver Cancer	p.G415A (No)	CCLE	Sorafenib	4.189
ACH-000988	Endometrial/Uterine Cancer	p.R429K (No)	CCLE	Panobinostat	0.0597
ACH-000988	Endometrial/Uterine Cancer	p.R429K (No)	CCLE	Sorafenib	8
ACH-000361	Liver Cancer	p.G433D (No)	CCLE	Panobinostat	0.041
ACH-000361	Liver Cancer	p.G433D (No)	CCLE	Sorafenib	8
ACH-000813	Lung Cancer	p.G356V (No)	CCLE	Panobinostat	0.0737
ACH-000813	Lung Cancer	p.G356V (No)	CCLE	Sorafenib	8
ACH-000643	Breast Cancer	p.R442C (No)	CCLE	Panobinostat	0.0426
ACH-000643	Breast Cancer	p.R442C (No)	CCLE	Sorafenib	8
ACH-000667	Lung Cancer	p.Q475K (No)	CCLE	Panobinostat	0.0689
ACH-000667	Lung Cancer	p.Q475K (No)	CCLE	Sorafenib	8
ACH-000971	Colon/Colorectal Cancer	p.Q510fs (No)	CCLE	Panobinostat	0.0404
ACH-000971	Colon/Colorectal Cancer	p.Q510fs (No)	CCLE	Sorafenib	6.2089
ACH-000766	Lung Cancer	p.G511W (No)	CCLE	Panobinostat	0.0861
ACH-000766	Lung Cancer	p.G511W (No)	CCLE	Sorafenib	8
ACH-000912	Lung Cancer	p.G434V (No)	CCLE	Panobinostat	0.0415
ACH-000912	Lung Cancer	p.G434V (No)	CCLE	Sorafenib	7.0014
ACH-000888	Lung Cancer	p.T527A (No)	CCLE	Sorafenib	8
ACH-000845	Lung Cancer	p.R451M (No)	CCLE	Panobinostat	0.1081
ACH-000845	Lung Cancer	p.R451M (No)	CCLE	Sorafenib	8
ACH-000980	Lung Cancer	p.A614V (No)	CCLE	Panobinostat	0.0455
ACH-000980	Lung Cancer	p.A614V (No)	CCLE	Sorafenib	8
ACH-000962	Ovarian Cancer	p.R670Q (No)	CCLE	Panobinostat	0.138
ACH-000962	Ovarian Cancer	p.R670Q (No)	CCLE	Sorafenib	8
ACH-001145	Ovarian Cancer	p.R670Q (No)	CCLE	Panobinostat	0.12
ACH-001145	Ovarian Cancer	p.R670Q (No)	CCLE	Sorafenib	8
ACH-000065	Leukemia	p.N705S (No)	CCLE	Panobinostat	0.0114
ACH-000065	Leukemia	p.N705S (No)	CCLE	Sorafenib	1.3256
ACH-000053	Lymphoma	p.G709R (No)	CCLE	Panobinostat	0.0623
ACH-000053	Lymphoma	p.G709R (No)	CCLE	Sorafenib	8
ACH-000627	Lung Cancer	p.D739V (No)	CCLE	Panobinostat	0.1041
ACH-000627	Lung Cancer	p.D739V (No)	CCLE	Sorafenib	8
ACH-000879	Endometrial/Uterine Cancer	p.R752H (No)	CCLE	Panobinostat	0.0605
ACH-000879	Endometrial/Uterine Cancer	p.R752H (No)	CCLE	Sorafenib	8
ACH-000811	Ovarian Cancer	p.C757S (No)	CCLE	Panobinostat	0.1414
ACH-000811	Ovarian Cancer	p.C757S (No)	CCLE	Sorafenib	8
ACH-000847	Gastric Cancer	p.D820H (No)	CCLE	Panobinostat	0.0389
ACH-000847	Gastric Cancer	p.D820H (No)	CCLE	Sorafenib	8
ACH-000987	Skin Cancer	p.G867E (No)	CCLE	Panobinostat	0.1065
ACH-000987	Skin Cancer	p.G867E (No)	CCLE	Sorafenib	8
ACH-000322	Skin Cancer	p.G886E (No)	CCLE	Panobinostat	0.088
ACH-000322	Skin Cancer	p.G886E (No)	CCLE	Sorafenib	8
ACH-000966	Ovarian Cancer	p.A915V (No)	CCLE	Panobinostat	0.0954
ACH-000966	Ovarian Cancer	p.A915V (No)	CCLE	Sorafenib	6.6023
ACH-001233	Lung Cancer	p.H956N (No)	CCLE	Panobinostat	0.0081
ACH-001233	Lung Cancer	p.H956N (No)	CCLE	Sorafenib	8
ACH-000900	Lung Cancer	p.G974* (No)	CCLE	Panobinostat	0.0654
ACH-000900	Lung Cancer	p.G974* (No)	CCLE	Sorafenib	8
ACH-000781	Lung Cancer	p.Q987L (No)	CCLE	Panobinostat	0.0933
ACH-000781	Lung Cancer	p.Q987L (No)	CCLE	Sorafenib	8
ACH-000745	Myeloma	p.L1030F (No)	CCLE	Panobinostat	0.018
ACH-000745	Myeloma	p.L1030F (No)	CCLE	Sorafenib	8
ACH-000899	Skin Cancer	p.V1037I (No)	CCLE	Panobinostat	0.0953
ACH-000899	Skin Cancer	p.V1037I (No)	CCLE	Sorafenib	8
ACH-000878	Lung Cancer	p.T1044K (No)	CCLE	Panobinostat	0.0431
ACH-000878	Lung Cancer	p.T1044K (No)	CCLE	Sorafenib	8
ACH-001318	Liver Cancer	p.A1052S (No)	CCLE	Panobinostat	0.0373
ACH-001318	Liver Cancer	p.A1052S (No)	CCLE	Sorafenib	8
ACH-000580	Skin Cancer	p.G1060C (No)	CCLE	Panobinostat	0.5973
ACH-000580	Skin Cancer	p.G1060C (No)	CCLE	Sorafenib	8
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	VNLG/124	8.7182
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	Trichostatin A	0.0873
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	Panobinostat	0.0083
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R260* (No)	GDSC	Trichostatin A	0.0167
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R260* (No)	GDSC	Panobinostat	0.0024
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	VNLG/124	46.9735
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	Trichostatin A	0.0429
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	Panobinostat	0.0095
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	Panobinostat	0.0334
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	VNLG/124	46.8364
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	Trichostatin A	0.2766
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	Panobinostat	0.058
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	VNLG/124	39.4529
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	Trichostatin A	0.2071
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	Panobinostat	0.0604
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	VNLG/124	34.5964
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	Trichostatin A	0.1391
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	Panobinostat	0.155
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	VNLG/124	38.6195
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	Trichostatin A	0.1967
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	Panobinostat	0.043
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	VNLG/124	16.6724
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	Trichostatin A	0.0608
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	Panobinostat	0.0037
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	VNLG/124	7.6646
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	Trichostatin A	0.0856
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	Panobinostat	0.0066
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	VNLG/124	7.6646
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	Trichostatin A	0.0856
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	Panobinostat	0.0066
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	VNLG/124	10.2625
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	Trichostatin A	0.2111
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	Panobinostat	0.0317
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	VNLG/124	33.0648
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	Trichostatin A	0.3686
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	Panobinostat	0.029
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (Yes)	GDSC	VNLG/124	8.7182
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (Yes)	GDSC	Trichostatin A	0.0873
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (Yes)	GDSC	Panobinostat	0.0083
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	VNLG/124	58.0382
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	Trichostatin A	0.143
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	Panobinostat	0.0482
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	VNLG/124	85.9408
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	Trichostatin A	0.1374
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	Panobinostat	0.0642
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	VNLG/124	54.201
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	Trichostatin A	0.226
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	Panobinostat	0.0496
SIDM00527	COREAD\|large_intestine	p.R311H (No)	GDSC	VNLG/124	61.6904
SIDM00527	COREAD\|large_intestine	p.R311H (No)	GDSC	Trichostatin A	0.2879
SIDM00527	COREAD\|large_intestine	p.R311H (No)	GDSC	Panobinostat	0.025
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	VNLG/124	41.2658
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	Trichostatin A	0.1661
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	Panobinostat	0.0493
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	VNLG/124	18.3585
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	Trichostatin A	0.0166
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	Panobinostat	0.0023
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	VNLG/124	82.2204
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	Trichostatin A	0.9894
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	Panobinostat	0.3117
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	VNLG/124	45.1726
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	Trichostatin A	0.3504
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	Panobinostat	0.1305
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	VNLG/124	45.1726
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	Trichostatin A	0.3504
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	Panobinostat	0.1305
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	VNLG/124	224.5319
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	Trichostatin A	2.0488
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	Panobinostat	0.8585
SIDM00126	SKCM\|melanoma	p.P924S (No)	GDSC	VNLG/124	76.4995
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	VNLG/124	132.7935
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	Trichostatin A	0.8621
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	Panobinostat	0.1676
SIDM00251	STAD\|stomach	p.E304K (No)	GDSC	VNLG/124	21.9133
SIDM00251	STAD\|stomach	p.E304K (No)	GDSC	Trichostatin A	0.1589
SIDM00251	STAD\|stomach	p.E304K (No)	GDSC	Panobinostat	0.111
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	VNLG/124	63.0929
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	Trichostatin A	0.1949
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	Panobinostat	0.0406
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	VNLG/124	46.3341
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	Trichostatin A	0.6267
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	Panobinostat	0.0518
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	VNLG/124	94.0787
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	Trichostatin A	0.2469
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	Panobinostat	0.0601
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	VNLG/124	8.888
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	Trichostatin A	0.0755
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	Panobinostat	0.0106
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	VNLG/124	67.0543
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	Trichostatin A	0.7506
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	Panobinostat	0.0494
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	VNLG/124	43.8004
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	Trichostatin A	0.063
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	Panobinostat	0.0079
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.H657Y (No)	GDSC	VNLG/124	16.7018
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.H657Y (No)	GDSC	Trichostatin A	0.0906
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	VNLG/124	26.9059
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	Trichostatin A	0.1294
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	Panobinostat	0.0165
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	VNLG/124	23.0783
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	Trichostatin A	0.1961
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	Panobinostat	0.0139
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	VNLG/124	38.0701
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	Trichostatin A	0.0681
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	Panobinostat	0.029
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	VNLG/124	69.5809
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	Trichostatin A	0.4566
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	Panobinostat	0.2065
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	VNLG/124	69.5809
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	Trichostatin A	0.4566
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	Panobinostat	0.2065
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	VNLG/124	19.5974
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	Trichostatin A	0.0572
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	Panobinostat	0.021
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	VNLG/124	22.6152
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	Trichostatin A	0.0798
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	Panobinostat	0.008
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	VNLG/124	42.2889
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	Trichostatin A	0.1885
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	Panobinostat	0.0494
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	VNLG/124	12.6789
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	Trichostatin A	0.402
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	Panobinostat	0.0672
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	VNLG/124	68.3252
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	Trichostatin A	0.1939
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	Panobinostat	0.0959
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	VNLG/124	59.6889
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	Trichostatin A	0.2542
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	Panobinostat	0.0291
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	VNLG/124	140.7267
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	Trichostatin A	24.6674
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	Panobinostat	26.5314
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	VNLG/124	140.7267
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	Trichostatin A	24.6674
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	Panobinostat	26.5314
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	VNLG/124	66.551
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	Trichostatin A	0.5086
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	Panobinostat	0.1247
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	VNLG/124	66.551
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	Trichostatin A	0.5086
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	Panobinostat	0.1247
SIDM00640	MESO\|mesothelioma	p.H381Q (Yes)	GDSC	VNLG/124	41.3922
SIDM00640	MESO\|mesothelioma	p.H381Q (Yes)	GDSC	Trichostatin A	0.3737
SIDM00640	MESO\|mesothelioma	p.H381Q (Yes)	GDSC	Panobinostat	0.1272
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	VNLG/124	50.1704
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	Trichostatin A	0.0489
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	Panobinostat	0.0104
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	VNLG/124	74.7738
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	Trichostatin A	0.2465
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	Panobinostat	0.0604
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.A142T (No)	GDSC	VNLG/124	28.523
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	VNLG/124	46.9735
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	Trichostatin A	0.0429
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	Panobinostat	0.0095
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	VNLG/124	142.837
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	Trichostatin A	0.2496
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	Panobinostat	0.0667
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	VNLG/124	4.9582
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	Trichostatin A	0.0887
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	Panobinostat	0.0171
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	VNLG/124	91.025
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	Trichostatin A	0.2171
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	Panobinostat	0.0472
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	Panobinostat	0.1073
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	VNLG/124	91.0538
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	Trichostatin A	0.971
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	Panobinostat	0.0967
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	VNLG/124	107.9185
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	Trichostatin A	0.1623
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	Panobinostat	0.0685
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	VNLG/124	79.1092
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	Trichostatin A	0.1509
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	Panobinostat	0.2047
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	Panobinostat	0.0334
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	Panobinostat	0.0334
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	VNLG/124	104.0033
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	Trichostatin A	0.2261
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	Panobinostat	0.1004
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	VNLG/124	56.1435
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	Trichostatin A	0.3061
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	Panobinostat	0.0618
SIDM00585	LIHC\|liver	p.M261I (No)	GDSC	VNLG/124	76.4064
SIDM00585	LIHC\|liver	p.M261I (No)	GDSC	Trichostatin A	1.1925
SIDM00585	LIHC\|liver	p.M261I (No)	GDSC	Panobinostat	1.0336
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	VNLG/124	77.3108
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	Trichostatin A	0.6175
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	Panobinostat	0.0997
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	VNLG/124	77.3108
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	Trichostatin A	0.6175
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	Panobinostat	0.0997
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	VNLG/124	21.5926
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	Trichostatin A	0.0698
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	Panobinostat	0.0235
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	VNLG/124	22.0655
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	Trichostatin A	0.4753
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	Panobinostat	0.0806
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	VNLG/124	68.4196
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	Trichostatin A	0.0415
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	Panobinostat	0.0151
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G1027R (No)	GDSC	Trichostatin A	0.0487
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G1027R (No)	GDSC	Panobinostat	0.017
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (Yes)	GDSC	VNLG/124	54.6187
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (Yes)	GDSC	Trichostatin A	0.2516
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (Yes)	GDSC	Panobinostat	0.0764
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (No)	GDSC	VNLG/124	75.2076
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (No)	GDSC	Trichostatin A	10.7702
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (No)	GDSC	Panobinostat	0.5964
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	VNLG/124	91.0599
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	Trichostatin A	0.2467
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	Panobinostat	0.156
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	VNLG/124	61.3947
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	Trichostatin A	0.4604
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	Panobinostat	0.299
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	VNLG/124	195.3063
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	Trichostatin A	1.3676
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	Panobinostat	0.5473
SIDM00383	UNCLASSIFIED\|stomach	p.A625V (No)	GDSC	VNLG/124	45.1114
SIDM00383	UNCLASSIFIED\|stomach	p.A625V (No)	GDSC	Trichostatin A	0.0528
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	VNLG/124	121.3447
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	Trichostatin A	0.38
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	Panobinostat	0.0399
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	VNLG/124	34.5057
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	Trichostatin A	0.2205
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	Panobinostat	0.2424
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	VNLG/124	53.5821
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	Trichostatin A	0.021
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	Panobinostat	0.0261
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	VNLG/124	20.4972
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	Trichostatin A	0.1897
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	Panobinostat	0.0684
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	VNLG/124	91.525
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	Trichostatin A	0.3886
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	Panobinostat	0.0311
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	VNLG/124	43.7393
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	Trichostatin A	0.7903
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	Panobinostat	0.3669
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	VNLG/124	28.4171
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	Trichostatin A	0.374
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	Panobinostat	0.0678
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	VNLG/124	84.9584
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	Trichostatin A	1.0881
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	Panobinostat	0.0976
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	VNLG/124	44.3849
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	Trichostatin A	0.1199
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	Panobinostat	0.0176
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	VNLG/124	132.1749
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	Trichostatin A	0.3336
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	Panobinostat	0.1051
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	VNLG/124	132.1749
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	Trichostatin A	0.3336
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	Panobinostat	0.1051
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	VNLG/124	50.3006
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	Trichostatin A	0.172
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	Panobinostat	0.0443

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFA1	Metalloprotease TIKI2	DEG_SPOP_SBC_1	487:491	PASSS	SPOP	0.9907	More...
O00303	Eukaryotic translation initiation factor 3 subunit F	DEG_SPOP_SBC_1	43:47	PASSS	SPOP	0.9551	More...
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	1181:1185	PASSS	SPOP	0.9968	More...
O75362	Zinc finger protein 217	DEG_SPOP_SBC_1	1005:1009	PASSS	SPOP	0.9854	More...
O75970	Multiple PDZ domain protein	DEG_SPOP_SBC_1	1960:1964	PASSS	SPOP	0.9899	More...
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	DEG_SPOP_SBC_1	1200:1204	PASSS	SPOP	0.9667	More...
O95155	Ubiquitin conjugation factor E4 B	DEG_SPOP_SBC_1	364:368	PASSS	SPOP	0.8802	More...
P14316	Interferon regulatory factor 2	DEG_SPOP_SBC_1	319:323	PASSS	SPOP	0.9874	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	168:172	PASSS	SPOP	0.9105	More...
P18850	Cyclic AMP-dependent transcription factor ATF-6 alpha	DEG_SPOP_SBC_1	95:99	PASSS	SPOP	0.978	More...
P23246	Splicing factor, proline- and glutamine-rich	DEG_SPOP_SBC_1	126:130	PASSS	SPOP	0.7045	More...
P23769	Endothelial transcription factor GATA-2	DEG_SPOP_SBC_1	193:197	PASSS	SPOP	0.9752	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	DEG_SPOP_SBC_1	135:139	PASSS	SPOP	0.9543	More...
P42568	Protein AF-9	DEG_SPOP_SBC_1	381:385	PASSS	SPOP	0.9981	More...
P46013	Proliferation marker protein Ki-67	DEG_SPOP_SBC_1	603:607	PASSS	SPOP	0.9325	More...
P46934	E3 ubiquitin-protein ligase NEDD4	DEG_SPOP_SBC_1	735:739	PASSS	SPOP	0.9912	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	826:830	PASSS	SPOP	0.8469	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	418:422	PASSS	SPOP	0.9161	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	374:378	PASSS	SPOP	0.9903	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	361:365	PASSS	SPOP	0.9939	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	120:124	PASSS	SPOP	0.9983	More...
Q0VG99	Mesoderm posterior protein 2	DEG_SPOP_SBC_1	33:37	PASSS	SPOP	0.9803	More...
Q13371	Phosducin-like protein	DEG_SPOP_SBC_1	37:41	PASSS	SPOP	0.8349	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	181:185	PASSS	SPOP	0.9721	More...
Q38SD2	Leucine-rich repeat serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1863:1867	PASSS	SPOP	0.9964	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	912:916	PASSS	SPOP	0.9473	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1293:1297	PASSS	SPOP	0.9018	More...
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	DEG_SPOP_SBC_1	100:104	PASSS	SPOP	0.9032	More...
Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	DEG_SPOP_SBC_1	625:629	PASSS	SPOP	0.7793	More...
Q68D10	Protein SPT2 homolog	DEG_SPOP_SBC_1	438:442	PASSS	SPOP	0.8937	More...
Q6IMN6	Caprin-2	DEG_SPOP_SBC_1	747:751	PASSS	SPOP	0.9991	More...
Q6NT76	Homeobox-containing protein 1	DEG_SPOP_SBC_1	80:84	PASSS	SPOP	0.9872	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	32:36	PASSS	SPOP	0.9463	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1772:1776	PASSS	SPOP	0.9504	More...
Q7Z353	Highly divergent homeobox	DEG_SPOP_SBC_1	113:117	PASSS	SPOP	0.9366	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	835:839	PASSS	SPOP	0.9992	More...
Q7Z7F0	KH homology domain-containing protein 4	DEG_SPOP_SBC_1	506:510	PASSS	SPOP	0.9505	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	477:481	PASSS	SPOP	0.9951	More...
Q8IZJ3	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8	DEG_SPOP_SBC_1	1763:1767	PASSS	SPOP	0.8309	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	320:324	PASSS	SPOP	0.8699	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	75:79	PASSS	SPOP	0.5416	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	221:225	PASSS	SPOP	0.9138	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SPOP_SBC_1	525:529	PASSS	SPOP	0.9993	More...
Q8TDY4	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	796:800	PASSS	SPOP	0.9822	More...
Q92575	UBX domain-containing protein 4	DEG_SPOP_SBC_1	454:458	PASSS	SPOP	0.9862	More...
Q92859	Neogenin	DEG_SPOP_SBC_1	1313:1317	PASSS	SPOP	0.9991	More...
Q96F86	Enhancer of mRNA-decapping protein 3	DEG_SPOP_SBC_1	107:111	PASSS	SPOP	0.9996	More...
Q96HA7	Tonsoku-like protein	DEG_SPOP_SBC_1	737:741	PASSS	SPOP	0.997	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	1381:1385	PASSS	SPOP	0.9788	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	539:543	PASSS	SPOP	0.9459	More...
Q99567	Nuclear pore complex protein Nup88	DEG_SPOP_SBC_1	42:46	PASSS	SPOP	0.7174	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	186:190	PASSS	SPOP	0.9979	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	287:291	PASSS	SPOP	0.6139	More...
Q9C0K0	B-cell lymphoma/leukemia 11B	DEG_SPOP_SBC_1	254:258	PASSS	SPOP	0.9929	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	814:818	PASSS	SPOP	0.9986	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	876:880	PASSS	SPOP	0.9947	More...
Q9NQI0	Probable ATP-dependent RNA helicase DDX4	DEG_SPOP_SBC_1	38:42	PASSS	SPOP	0.9918	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	83:87	PASSS	SPOP	0.9888	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1491:1495	PASSS	SPOP	0.9916	More...
Q9NRE2	Teashirt homolog 2	DEG_SPOP_SBC_1	810:814	PASSS	SPOP	0.9825	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	104:108	PASSS	SPOP	0.9313	More...
Q9NT99	Leucine-rich repeat-containing protein 4B	DEG_SPOP_SBC_1	533:537	PASSS	SPOP	0.5598	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_SPOP_SBC_1	377:381	PASSS	SPOP	0.7362	More...
Q9UFE4	Coiled-coil domain-containing protein 39	DEG_SPOP_SBC_1	912:916	PASSS	SPOP	0.8568	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	201:205	PASSS	SPOP	0.9533	More...
Q9UK96	F-box only protein 10	DEG_SPOP_SBC_1	322:326	PASSS	SPOP	0.9634	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	5092:5096	PASSS	SPOP	0.9859	More...
Q9UKV0	Histone deacetylase 9	DEG_SPOP_SBC_1	373:377	PASSS	SPOP	0.9671	More...
Q9UL51	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	DEG_SPOP_SBC_1	840:844	PASSS	SPOP	0.9968	More...
Q9UPE1	SRSF protein kinase 3	DEG_SPOP_SBC_1	331:335	PASSS	SPOP	0.9871	More...
Q9Y468	Lethal	DEG_SPOP_SBC_1	72:76	PASSS	SPOP	0.8513	More...
Q9Y4W2	Ribosomal biogenesis protein LAS1L	DEG_SPOP_SBC_1	541:545	PASSS	SPOP	0.991	More...
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_SPOP_SBC_1	2612:2616	PASSS	SPOP	0.9348	More...
Q5VWJ9	Sorting nexin-30	DEG_SPOP_SBC_1	68:72	PASSS	SPOP	0.9989	More...
Q6P3S6	F-box only protein 42	DEG_SPOP_SBC_1	508:512	PASSS	SPOP	0.9901	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	28:32	PASSS	SPOP	0.6153	More...
Q6ZWK6	Transmembrane protease serine 11F	DEG_SPOP_SBC_1	198:202	PASSS	SPOP	0.5476	More...
Q8NFJ8	Class E basic helix-loop-helix protein 22	DEG_SPOP_SBC_1	54:58	PASSS	SPOP	0.9164	More...
Q9BWU0	Kanadaptin	DEG_SPOP_SBC_1	90:94	PASSS	SPOP	0.9791	More...
Q9BXK1	Krueppel-like factor 16	DEG_SPOP_SBC_1	100:104	PASSS	SPOP	0.9984	More...
Q9UPV7	PHD finger protein 24	DEG_SPOP_SBC_1	349:353	PASSS	SPOP	0.959	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	156:160	PASSS	SPOP	0.5793	More...
Q8IYL3	UPF0688 protein C1orf174	DEG_SPOP_SBC_1	210:214	PASSS	SPOP	0.9988	More...
Q96KN9	Gap junction delta-4 protein	DEG_SPOP_SBC_1	353:357	PASSS	SPOP	0.9456	More...
Q9NXJ0	Membrane-spanning 4-domains subfamily A member 12	DEG_SPOP_SBC_1	249:253	PASSS	SPOP	0.9403	More...
Q8N377	Putative uncharacterized protein LOC387726	DEG_SPOP_SBC_1	14:18	PASSS	SPOP	0.9939	More...
Q8N377	Putative uncharacterized protein LOC387726	DEG_SPOP_SBC_1	25:29	PASSS	SPOP	0.9827	More...
Q8N377	Putative uncharacterized protein LOC387726	DEG_SPOP_SBC_1	36:40	PASSS	SPOP	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASSS

Degron related mutations and impact score

Drug responses associated with HDAC9 mutations

All proteins holding degron of PASSS