Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
Organism: Hsapiens, Id Type: entrezgene, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene set are listed in this table. For each gene set, the first row lists the gene set name, and corresponding Gene Set ID. The second row lists number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP). Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.
Wikipathways pathway----TGF Beta Signaling Pathway----WP560
C=61;O=23;E=0.48;R=47.69;rawP=6.09e-33;adjP=8.95e-31
7040 NA 7040 ENSG00000105329 TGFB1 transforming growth factor, beta 1
7124 NA 7124 ENSG00000232810 TNF tumor necrosis factor
7471 NA 7471 ENSG00000125084 WNT1 wingless-type MMTV integration site family, member 1
4093 NA 4093 ENSG00000120693 SMAD9 SMAD family member 9
1950 NA 1950 ENSG00000138798 EGF epidermal growth factor
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
7046 NA 7046 ENSG00000106799 TGFBR1 transforming growth factor, beta receptor 1
4090 NA 4090 ENSG00000113658 SMAD5 SMAD family member 5
2353 NA 2353 ENSG00000170345 FOS FBJ murine osteosarcoma viral oncogene homolog
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
7057 NA 7057 ENSG00000137801 THBS1 thrombospondin 1
2022 NA 2022 ENSG00000106991 ENG endoglin
4088 NA 4088 ENSG00000166949 SMAD3 SMAD family member 3
6696 NA 6696 ENSG00000118785 SPP1 secreted phosphoprotein 1
7049 NA 7049 ENSG00000069702 TGFBR3 transforming growth factor, beta receptor III
4087 NA 4087 ENSG00000175387 SMAD2 SMAD family member 2
1499 NA 1499 ENSG00000168036 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
6772 NA 6772 ENSG00000115415 STAT1 signal transducer and activator of transcription 1, 91kDa
5054 NA 5054 ENSG00000106366 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
652 NA 652 ENSG00000125378 BMP4 bone morphogenetic protein 4
4086 NA 4086 ENSG00000170365 SMAD1 SMAD family member 1
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
4089 NA 4089 ENSG00000141646 SMAD4 SMAD family member 4
Wikipathways pathway----Integrated Pancreatic Cancer Pathway----WP2256
C=181;O=31;E=1.43;R=21.66;rawP=4.62e-32;adjP=3.40e-30
7040 NA 7040 ENSG00000105329 TGFB1 transforming growth factor, beta 1
7124 NA 7124 ENSG00000232810 TNF tumor necrosis factor
1394 NA 1394 ENSG00000120088 CRHR1 corticotropin releasing hormone receptor 1
207 NA 207 ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1
5163 NA 5163 ENSG00000152256 PDK1 pyruvate dehydrogenase kinase, isozyme 1
842 NA 842 ENSG00000132906 CASP9 caspase 9, apoptosis-related cysteine peptidase
1950 NA 1950 ENSG00000138798 EGF epidermal growth factor
7157 NA 7157 ENSG00000141510 TP53 tumor protein p53
7046 NA 7046 ENSG00000106799 TGFBR1 transforming growth factor, beta receptor 1
2100 NA 2100 ENSG00000140009 ESR2 estrogen receptor 2 (ER beta)
5578 NA 5578 ENSG00000154229 PRKCA protein kinase C, alpha
7422 NA 7422 ENSG00000112715 VEGFA vascular endothelial growth factor A
5156 NA 5156 ENSG00000134853 PDGFRA platelet-derived growth factor receptor, alpha polypeptide
4485 NA 4485 ENSG00000173531 MST1 macrophage stimulating 1 (hepatocyte growth factor-like)
6714 NA 6714 ENSG00000197122 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
1605 NA 1605 ENSG00000173402 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
1956 NA 1956 ENSG00000146648 EGFR epidermal growth factor receptor
7057 NA 7057 ENSG00000137801 THBS1 thrombospondin 1
5154 NA 5154 ENSG00000197461 PDGFA platelet-derived growth factor alpha polypeptide
3554 NA 3554 ENSG00000115594 IL1R1 interleukin 1 receptor, type I
595 NA 595 ENSG00000110092 CCND1 cyclin D1
5743 NA 5743 ENSG00000073756 PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
4087 NA 4087 ENSG00000175387 SMAD2 SMAD family member 2
1499 NA 1499 ENSG00000168036 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
6772 NA 6772 ENSG00000115415 STAT1 signal transducer and activator of transcription 1, 91kDa
135 NA 135 ENSG00000128271 ADORA2A adenosine A2a receptor
1027 NA 1027 ENSG00000111276 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
841 NA 841 ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
2099 NA 2099 ENSG00000091831 ESR1 estrogen receptor 1
4089 NA 4089 ENSG00000141646 SMAD4 SMAD family member 4
Wikipathways pathway----Focal Adhesion----WP306
C=185;O=24;E=1.46;R=16.41;rawP=4.38e-22;adjP=2.15e-20
387 NA 387 ENSG00000067560 RHOA ras homolog family member A
207 NA 207 ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1
2335 NA 2335 ENSG00000115414 FN1 fibronectin 1
3791 NA 3791 ENSG00000128052 KDR kinase insert domain receptor (a type III receptor tyrosine kinase)
1950 NA 1950 ENSG00000138798 EGF epidermal growth factor
857 NA 857 ENSG00000105974 CAV1 caveolin 1, caveolae protein, 22kDa
5156 NA 5156 ENSG00000134853 PDGFRA platelet-derived growth factor receptor, alpha polypeptide
5155 NA 5155 ENSG00000100311 PDGFB platelet-derived growth factor beta polypeptide
6714 NA 6714 ENSG00000197122 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
3371 NA 3371 ENSG00000041982 TNC tenascin C
1956 NA 1956 ENSG00000146648 EGFR epidermal growth factor receptor
388 NA 388 ENSG00000143878 RHOB ras homolog family member B
7057 NA 7057 ENSG00000137801 THBS1 thrombospondin 1
5154 NA 5154 ENSG00000197461 PDGFA platelet-derived growth factor alpha polypeptide
595 NA 595 ENSG00000110092 CCND1 cyclin D1
6696 NA 6696 ENSG00000118785 SPP1 secreted phosphoprotein 1
3480 NA 3480 ENSG00000140443 IGF1R insulin-like growth factor 1 receptor
3913 NA 3913 ENSG00000172037 LAMB2 laminin, beta 2 (laminin S)
7450 NA 7450 ENSG00000110799 VWF von Willebrand factor
3082 NA 3082 ENSG00000019991 HGF hepatocyte growth factor (hepapoietin A; scatter factor)
6093 NA 6093 ENSG00000067900 ROCK1 Rho-associated, coiled-coil containing protein kinase 1
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
9475 NA 9475 ENSG00000134318 ROCK2 Rho-associated, coiled-coil containing protein kinase 2
5159 NA 5159 ENSG00000113721 PDGFRB platelet-derived growth factor receptor, beta polypeptide
Wikipathways pathway----AGE-RAGE pathway----WP2324
C=76;O=18;E=0.60;R=29.95;rawP=7.69e-22;adjP=2.43e-20
4318 NA 4318 ENSG00000100985 MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
387 NA 387 ENSG00000067560 RHOA ras homolog family member A
207 NA 207 ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1
842 NA 842 ENSG00000132906 CASP9 caspase 9, apoptosis-related cysteine peptidase
5578 NA 5578 ENSG00000154229 PRKCA protein kinase C, alpha
6714 NA 6714 ENSG00000197122 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
1956 NA 1956 ENSG00000146648 EGFR epidermal growth factor receptor
4088 NA 4088 ENSG00000166949 SMAD3 SMAD family member 3
4087 NA 4087 ENSG00000175387 SMAD2 SMAD family member 2
3091 NA 3091 ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
4313 NA 4313 ENSG00000087245 MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
6772 NA 6772 ENSG00000115415 STAT1 signal transducer and activator of transcription 1, 91kDa
6093 NA 6093 ENSG00000067900 ROCK1 Rho-associated, coiled-coil containing protein kinase 1
841 NA 841 ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
4843 NA 4843 ENSG00000007171 NOS2 nitric oxide synthase 2, inducible
4846 NA 4846 ENSG00000164867 NOS3 nitric oxide synthase 3 (endothelial cell)
Wikipathways pathway----SIDS Susceptibility Pathways----WP706
C=214;O=25;E=1.69;R=14.77;rawP=8.25e-22;adjP=2.43e-20
7124 NA 7124 ENSG00000232810 TNF tumor necrosis factor
7433 NA 7433 ENSG00000114812 VIPR1 vasoactive intestinal peptide receptor 1
6331 NA 6331 ENSG00000183873 SCN5A sodium channel, voltage-gated, type V, alpha subunit
7166 NA 7166 ENSG00000129167 TPH1 tryptophan hydroxylase 1
3596 NA 3596 ENSG00000169194 IL13 interleukin 13
6262 NA 6262 ENSG00000198626 RYR2 ryanodine receptor 2 (cardiac)
5460 NA 5460 ENSG00000204531 POU5F1 POU class 5 homeobox 1
2100 NA 2100 ENSG00000140009 ESR2 estrogen receptor 2 (ER beta)
3552 NA 3552 ENSG00000115008 IL1A interleukin 1, alpha
7422 NA 7422 ENSG00000112715 VEGFA vascular endothelial growth factor A
5566 NA 5566 ENSG00000072062 PRKACA protein kinase, cAMP-dependent, catalytic, alpha
1051 NA 1051 ENSG00000172216 CEBPB CCAAT/enhancer binding protein (C/EBP), beta
1499 NA 1499 ENSG00000168036 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
6532 NA 6532 ENSG00000108576 SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
3091 NA 3091 ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
3569 NA 3569 ENSG00000136244 IL6 interleukin 6 (interferon, beta 2)
4128 NA 4128 ENSG00000189221 MAOA monoamine oxidase A
388585 NA 388585 ENSG00000197921 HES5 hairy and enhancer of split 5 (Drosophila)
3065 NA 3065 ENSG00000116478 HDAC1 histone deacetylase 1
7054 NA 7054 ENSG00000180176 TH tyrosine hydroxylase
6863 NA 6863 ENSG00000006128 TAC1 tachykinin, precursor 1
1889 NA 1889 ENSG00000117298 ECE1 endothelin converting enzyme 1
4791 NA 4791 ENSG00000077150 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
10891 NA 10891 ENSG00000109819 PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
7434 NA 7434 ENSG00000106018 VIPR2 vasoactive intestinal peptide receptor 2
Wikipathways pathway----MAPK signaling pathway----WP382
C=165;O=21;E=1.30;R=16.10;rawP=2.65e-19;adjP=6.49e-18
7040 NA 7040 ENSG00000105329 TGFB1 transforming growth factor, beta 1
7124 NA 7124 ENSG00000232810 TNF tumor necrosis factor
468 NA 468 ENSG00000128272 ATF4 activating transcription factor 4 (tax-responsive enhancer element B67)
207 NA 207 ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1
3309 NA 3309 ENSG00000044574 HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
842 NA 842 ENSG00000132906 CASP9 caspase 9, apoptosis-related cysteine peptidase
1950 NA 1950 ENSG00000138798 EGF epidermal growth factor
7157 NA 7157 ENSG00000141510 TP53 tumor protein p53
7046 NA 7046 ENSG00000106799 TGFBR1 transforming growth factor, beta receptor 1
3552 NA 3552 ENSG00000115008 IL1A interleukin 1, alpha
2353 NA 2353 ENSG00000170345 FOS FBJ murine osteosarcoma viral oncogene homolog
5566 NA 5566 ENSG00000072062 PRKACA protein kinase, cAMP-dependent, catalytic, alpha
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
5155 NA 5155 ENSG00000100311 PDGFB platelet-derived growth factor beta polypeptide
1956 NA 1956 ENSG00000146648 EGFR epidermal growth factor receptor
3554 NA 3554 ENSG00000115594 IL1R1 interleukin 1 receptor, type I
841 NA 841 ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
1849 NA 1849 ENSG00000164086 DUSP7 dual specificity phosphatase 7
5159 NA 5159 ENSG00000113721 PDGFRB platelet-derived growth factor receptor, beta polypeptide
1843 NA 1843 ENSG00000120129 DUSP1 dual specificity phosphatase 1
Wikipathways pathway----Oncostatin M Signaling Pathway----WP2358
C=85;O=16;E=0.67;R=23.81;rawP=7.88e-18;adjP=1.65e-16
207 NA 207 ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1
6347 NA 6347 ENSG00000108691 CCL2 chemokine (C-C motif) ligand 2
7157 NA 7157 ENSG00000141510 TP53 tumor protein p53
4312 NA 4312 ENSG00000196611 MMP1 matrix metallopeptidase 1 (interstitial collagenase)
5578 NA 5578 ENSG00000154229 PRKCA protein kinase C, alpha
2353 NA 2353 ENSG00000170345 FOS FBJ murine osteosarcoma viral oncogene homolog
6714 NA 6714 ENSG00000197122 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
595 NA 595 ENSG00000110092 CCND1 cyclin D1
1051 NA 1051 ENSG00000172216 CEBPB CCAAT/enhancer binding protein (C/EBP), beta
4314 NA 4314 ENSG00000149968 MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase)
7076 NA 7076 ENSG00000102265 TIMP1 TIMP metallopeptidase inhibitor 1
6772 NA 6772 ENSG00000115415 STAT1 signal transducer and activator of transcription 1, 91kDa
1027 NA 1027 ENSG00000111276 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
5054 NA 5054 ENSG00000106366 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
Wikipathways pathway----TGF beta Signaling Pathway----WP366
C=148;O=19;E=1.17;R=16.24;rawP=1.17e-17;adjP=2.15e-16
7040 NA 7040 ENSG00000105329 TGFB1 transforming growth factor, beta 1
387 NA 387 ENSG00000067560 RHOA ras homolog family member A
207 NA 207 ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1
5163 NA 5163 ENSG00000152256 PDK1 pyruvate dehydrogenase kinase, isozyme 1
7157 NA 7157 ENSG00000141510 TP53 tumor protein p53
4092 NA 4092 ENSG00000101665 SMAD7 SMAD family member 7
7046 NA 7046 ENSG00000106799 TGFBR1 transforming growth factor, beta receptor 1
857 NA 857 ENSG00000105974 CAV1 caveolin 1, caveolae protein, 22kDa
2353 NA 2353 ENSG00000170345 FOS FBJ murine osteosarcoma viral oncogene homolog
7048 NA 7048 ENSG00000163513 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
6714 NA 6714 ENSG00000197122 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
595 NA 595 ENSG00000110092 CCND1 cyclin D1
4088 NA 4088 ENSG00000166949 SMAD3 SMAD family member 3
7049 NA 7049 ENSG00000069702 TGFBR3 transforming growth factor, beta receptor III
4087 NA 4087 ENSG00000175387 SMAD2 SMAD family member 2
3065 NA 3065 ENSG00000116478 HDAC1 histone deacetylase 1
57154 NA 57154 ENSG00000198742 SMURF1 SMAD specific E3 ubiquitin protein ligase 1
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
4089 NA 4089 ENSG00000141646 SMAD4 SMAD family member 4
Wikipathways pathway----Adipogenesis----WP236
C=130;O=18;E=1.03;R=17.51;rawP=2.14e-17;adjP=3.50e-16
7040 NA 7040 ENSG00000105329 TGFB1 transforming growth factor, beta 1
7124 NA 7124 ENSG00000232810 TNF tumor necrosis factor
7471 NA 7471 ENSG00000125084 WNT1 wingless-type MMTV integration site family, member 1
5468 NA 5468 ENSG00000132170 PPARG peroxisome proliferator-activated receptor gamma
650 NA 650 ENSG00000125845 BMP2 bone morphogenetic protein 2
4088 NA 4088 ENSG00000166949 SMAD3 SMAD family member 3
1051 NA 1051 ENSG00000172216 CEBPB CCAAT/enhancer binding protein (C/EBP), beta
1499 NA 1499 ENSG00000168036 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
3091 NA 3091 ENSG00000100644 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
3569 NA 3569 ENSG00000136244 IL6 interleukin 6 (interferon, beta 2)
5740 NA 5740 ENSG00000124212 PTGIS prostaglandin I2 (prostacyclin) synthase
6772 NA 6772 ENSG00000115415 STAT1 signal transducer and activator of transcription 1, 91kDa
3952 NA 3952 ENSG00000174697 LEP leptin
5054 NA 5054 ENSG00000106366 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
688 NA 688 ENSG00000102554 KLF5 Kruppel-like factor 5 (intestinal)
652 NA 652 ENSG00000125378 BMP4 bone morphogenetic protein 4
10891 NA 10891 ENSG00000109819 PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
6774 NA 6774 ENSG00000168610 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
Wikipathways pathway----Senescence and Autophagy----WP615
C=120;O=17;E=0.95;R=17.92;rawP=1.13e-16;adjP=1.66e-15
7040 NA 7040 ENSG00000105329 TGFB1 transforming growth factor, beta 1
2335 NA 2335 ENSG00000115414 FN1 fibronectin 1
7157 NA 7157 ENSG00000141510 TP53 tumor protein p53
3552 NA 3552 ENSG00000115008 IL1A interleukin 1, alpha
6714 NA 6714 ENSG00000197122 SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
7057 NA 7057 ENSG00000137801 THBS1 thrombospondin 1
650 NA 650 ENSG00000125845 BMP2 bone morphogenetic protein 2
4088 NA 4088 ENSG00000166949 SMAD3 SMAD family member 3
1051 NA 1051 ENSG00000172216 CEBPB CCAAT/enhancer binding protein (C/EBP), beta
3480 NA 3480 ENSG00000140443 IGF1R insulin-like growth factor 1 receptor
3569 NA 3569 ENSG00000136244 IL6 interleukin 6 (interferon, beta 2)
1027 NA 1027 ENSG00000111276 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
5054 NA 5054 ENSG00000106366 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
6348 NA 6348 ENSG00000006075 CCL3 chemokine (C-C motif) ligand 3
960 NA 960 ENSG00000026508 CD44 CD44 molecule (Indian blood group)
5594 NA 5594 ENSG00000100030 MAPK1 mitogen-activated protein kinase 1
4089 NA 4089 ENSG00000141646 SMAD4 SMAD family member 4


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