Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
Entrez Gene IDGene NameDescription
10059

DNM1L

dynamin 1-like

10168

ZNF197

zinc finger protein 197

10194

TSHZ1

teashirt zinc finger homeobox 1

10201

NME6

NME/NM23 nucleoside diphosphate kinase 6

1027

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

10399

GNB2L1

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

10425

ARIH2

ariadne homolog 2 (Drosophila)

1051

CEBPB

CCAAT/enhancer binding protein (C/EBP), beta

10614

HEXIM1

hexamethylene bis-acetamide inducible 1

10663

CXCR6

chemokine (C-X-C motif) receptor 6

10666

CD226

CD226 molecule

1072

CFL1

cofilin 1 (non-muscle)

1073

CFL2

cofilin 2 (muscle)

10746

MAP3K2

mitogen-activated protein kinase kinase kinase 2

10891

PPARGC1A

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

10911

UTS2

urotensin 2

10956

OS9

osteosarcoma amplified 9, endoplasmic reticulum lectin

114907

FBXO32

F-box protein 32

1230

CCR1

chemokine (C-C motif) receptor 1

1236

CCR7

chemokine (C-C motif) receptor 7

125704

FAM69C

family with sequence similarity 69, member C

134549

SHROOM1

shroom family member 1

135

ADORA2A

adenosine A2a receptor

1361

CPB2

carboxypeptidase B2 (plasma)

1373

CPS1

carbamoyl-phosphate synthase 1, mitochondrial

1394

CRHR1

corticotropin releasing hormone receptor 1

1401

CRP

C-reactive protein, pentraxin-related

147381

CBLN2

cerebellin 2 precursor

1490

CTGF

connective tissue growth factor

1491

CTH

cystathionase (cystathionine gamma-lyase)

1499

CTNNB1

catenin (cadherin-associated protein), beta 1, 88kDa

1524

CX3CR1

chemokine (C-X3-C motif) receptor 1

1535

CYBA

cytochrome b-245, alpha polypeptide

1545

CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

1588

CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

1605

DAG1

dystroglycan 1 (dystrophin-associated glycoprotein 1)

1636

ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

1843

DUSP1

dual specificity phosphatase 1

1849

DUSP7

dual specificity phosphatase 7

185

AGTR1

angiotensin II receptor, type 1

187

APLNR

apelin receptor

1889

ECE1

endothelin converting enzyme 1

1906

EDN1

endothelin 1

1907

EDN2

endothelin 2

1908

EDN3

endothelin 3

1909

EDNRA

endothelin receptor type A

1910

EDNRB

endothelin receptor type B

1950

EGF

epidermal growth factor

1956

EGFR

epidermal growth factor receptor

2006

ELN

elastin

201456

FBXO15

F-box protein 15

2022

ENG

endoglin

207

AKT1

v-akt murine thymoma viral oncogene homolog 1

2099

ESR1

estrogen receptor 1

2100

ESR2

estrogen receptor 2 (ER beta)

2101

ESRRA

estrogen-related receptor alpha

2103

ESRRB

estrogen-related receptor beta

2104

ESRRG

estrogen-related receptor gamma

2150

F2RL1

coagulation factor II (thrombin) receptor-like 1

2273

FHL1

four and a half LIM domains 1

22926

ATF6

activating transcription factor 6

2294

FOXF1

forkhead box F1

2335

FN1

fibronectin 1

23365

ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12

23417

MLYCD

malonyl-CoA decarboxylase

2353

FOS

FBJ murine osteosarcoma viral oncogene homolog

2355

FOSL2

FOS-like antigen 2

240

ALOX5

arachidonate 5-lipoxygenase

259236

TMIE

transmembrane inner ear

26284

ERAL1

Era G-protein-like 1 (E. coli)

2643

GCH1

GTP cyclohydrolase 1

2658

GDF2

growth differentiation factor 2

26585

GREM1

gremlin 1, DAN family BMP antagonist

27302

BMP10

bone morphogenetic protein 10

2779

GNAT1

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

2837

UTS2R

urotensin 2 receptor

284

ANGPT1

angiopoietin 1

284273

ZADH2

zinc binding alcohol dehydrogenase domain containing 2

2852

GPER

G protein-coupled estrogen receptor 1

29090

TIMM21

translocase of inner mitochondrial membrane 21 homolog (yeast)

2977

GUCY1A2

guanylate cyclase 1, soluble, alpha 2

2982

GUCY1A3

guanylate cyclase 1, soluble, alpha 3

2983

GUCY1B3

guanylate cyclase 1, soluble, beta 3

29843

SENP1

SUMO1/sentrin specific peptidase 1

3028

HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10

3037

HAS2

hyaluronan synthase 2

3065

HDAC1

histone deacetylase 1

30819

KCNIP2

Kv channel interacting protein 2

3082

HGF

hepatocyte growth factor (hepapoietin A; scatter factor)

3091

HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

3099

HK2

hexokinase 2

3115

HLA-DPB1

major histocompatibility complex, class II, DP beta 1

3119

HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

3123

HLA-DRB1

major histocompatibility complex, class II, DR beta 1

3127

HLA-DRB5

major histocompatibility complex, class II, DR beta 5

3156

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

3162

HMOX1

heme oxygenase (decycling) 1

3292

HSD17B1

hydroxysteroid (17-beta) dehydrogenase 1

3293

HSD17B3

hydroxysteroid (17-beta) dehydrogenase 3

3294

HSD17B2

hydroxysteroid (17-beta) dehydrogenase 2

3295

HSD17B4

hydroxysteroid (17-beta) dehydrogenase 4

3309

HSPA5

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

331

XIAP

X-linked inhibitor of apoptosis

3337

DNAJB1

DnaJ (Hsp40) homolog, subfamily B, member 1

3351

HTR1B

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

3357

HTR2B

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

3371

TNC

tenascin C

3383

ICAM1

intercellular adhesion molecule 1

3397

ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

3398

ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

345275

HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

348

APOE

apolipoprotein E

3480

IGF1R

insulin-like growth factor 1 receptor

3552

IL1A

interleukin 1, alpha

3554

IL1R1

interleukin 1 receptor, type I

3569

IL6

interleukin 6 (interferon, beta 2)

3596

IL13

interleukin 13

3598

IL13RA2

interleukin 13 receptor, alpha 2

3627

CXCL10

chemokine (C-X-C motif) ligand 10

3662

IRF4

interferon regulatory factor 4

3741

KCNA5

potassium voltage-gated channel, shaker-related subfamily, member 5

3791

KDR

kinase insert domain receptor (a type III receptor tyrosine kinase)

384

ARG2

arginase, type II

386724

AMIGO3

adhesion molecule with Ig-like domain 3

387

RHOA

ras homolog family member A

388

RHOB

ras homolog family member B

388585

HES5

hairy and enhancer of split 5 (Drosophila)

3913

LAMB2

laminin, beta 2 (laminin S)

3952

LEP

leptin

3953

LEPR

leptin receptor

3984

LIMK1

LIM domain kinase 1

4035

LRP1

low density lipoprotein receptor-related protein 1

4086

SMAD1

SMAD family member 1

4087

SMAD2

SMAD family member 2

4088

SMAD3

SMAD family member 3

4089

SMAD4

SMAD family member 4

4090

SMAD5

SMAD family member 5

4092

SMAD7

SMAD family member 7

4093

SMAD9

SMAD family member 9

4128

MAOA

monoamine oxidase A

4134

MAP4

microtubule-associated protein 4

4223

MEOX2

mesenchyme homeobox 2

4312

MMP1

matrix metallopeptidase 1 (interstitial collagenase)

4313

MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

4314

MMP3

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

4318

MMP9

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

4485

MST1

macrophage stimulating 1 (hepatocyte growth factor-like)

468

ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

4773

NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

4775

NFATC3

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

4791

NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

4842

NOS1

nitric oxide synthase 1 (neuronal)

4843

NOS2

nitric oxide synthase 2, inducible

4846

NOS3

nitric oxide synthase 3 (endothelial cell)

4851

NOTCH1

notch 1

4854

NOTCH3

notch 3

4879

NPPB

natriuretic peptide B

5037

PEBP1

phosphatidylethanolamine binding protein 1

50507

NOX4

NADPH oxidase 4

5054

SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

51099

ABHD5

abhydrolase domain containing 5

51144

HSD17B12

hydroxysteroid (17-beta) dehydrogenase 12

51170

HSD17B11

hydroxysteroid (17-beta) dehydrogenase 11

51171

HSD17B14

hydroxysteroid (17-beta) dehydrogenase 14

51188

SS18L2

synovial sarcoma translocation gene on chromosome 18-like 2

5136

PDE1A

phosphodiesterase 1A, calmodulin-dependent

5137

PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

51378

ANGPT4

angiopoietin 4

51385

ZNF589

zinc finger protein 589

51478

HSD17B7

hydroxysteroid (17-beta) dehydrogenase 7

51517

NCKIPSD

NCK interacting protein with SH3 domain

5154

PDGFA

platelet-derived growth factor alpha polypeptide

5155

PDGFB

platelet-derived growth factor beta polypeptide

51554

CCRL1

chemokine (C-C motif) receptor-like 1

5156

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

5157

PDGFRL

platelet-derived growth factor receptor-like

5159

PDGFRB

platelet-derived growth factor receptor, beta polypeptide

5160

PDHA1

pyruvate dehydrogenase (lipoamide) alpha 1

5163

PDK1

pyruvate dehydrogenase kinase, isozyme 1

5164

PDK2

pyruvate dehydrogenase kinase, isozyme 2

5165

PDK3

pyruvate dehydrogenase kinase, isozyme 3

5166

PDK4

pyruvate dehydrogenase kinase, isozyme 4

5265

SERPINA1

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

5292

PIM1

pim-1 oncogene

5460

POU5F1

POU class 5 homeobox 1

5468

PPARG

peroxisome proliferator-activated receptor gamma

55107

ANO1

anoctamin 1, calcium activated chloride channel

55193

PBRM1

polybromo 1

5551

PRF1

perforin 1 (pore forming protein)

5566

PRKACA

protein kinase, cAMP-dependent, catalytic, alpha

55748

CNDP2

CNDP dipeptidase 2 (metallopeptidase M20 family)

5578

PRKCA

protein kinase C, alpha

5592

PRKG1

protein kinase, cGMP-dependent, type I

5594

MAPK1

mitogen-activated protein kinase 1

5617

PRL

prolactin

56937

PMEPA1

prostate transmembrane protein, androgen induced 1

57060

PCBP4

poly(rC) binding protein 4

57142

RTN4

reticulon 4

57154

SMURF1

SMAD specific E3 ubiquitin protein ligase 1

5739

PTGIR

prostaglandin I2 (prostacyclin) receptor (IP)

5740

PTGIS

prostaglandin I2 (prostacyclin) synthase

5743

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

57626

KLHL1

kelch-like family member 1

59272

ACE2

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

59341

TRPV4

transient receptor potential cation channel, subfamily V, member 4

595

CCND1

cyclin D1

6093

ROCK1

Rho-associated, coiled-coil containing protein kinase 1

6159

RPL29

ribosomal protein L29

6259

RYK

receptor-like tyrosine kinase

6262

RYR2

ryanodine receptor 2 (cardiac)

6275

S100A4

S100 calcium binding protein A4

6331

SCN5A

sodium channel, voltage-gated, type V, alpha subunit

6347

CCL2

chemokine (C-C motif) ligand 2

6348

CCL3

chemokine (C-C motif) ligand 3

6387

CXCL12

chemokine (C-X-C motif) ligand 12

644041

C18orf63

chromosome 18 open reading frame 63

6462

SHBG

sex hormone-binding globulin

64881

PCDH20

protocadherin 20

650

BMP2

bone morphogenetic protein 2

652

BMP4

bone morphogenetic protein 4

6532

SLC6A4

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

657

BMPR1A

bone morphogenetic protein receptor, type IA

658

BMPR1B

bone morphogenetic protein receptor, type IB

659

BMPR2

bone morphogenetic protein receptor, type II (serine/threonine kinase)

6648

SOD2

superoxide dismutase 2, mitochondrial

6696

SPP1

secreted phosphoprotein 1

6714

SRC

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

6715

SRD5A1

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

6772

STAT1

signal transducer and activator of transcription 1, 91kDa

6774

STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

6863

TAC1

tachykinin, precursor 1

688

KLF5

Kruppel-like factor 5 (intestinal)

6915

TBXA2R

thromboxane A2 receptor

6988

TCTA

T-cell leukemia translocation altered

6993

DYNLT1

dynein, light chain, Tctex-type 1

7010

TEK

TEK tyrosine kinase, endothelial

7040

TGFB1

transforming growth factor, beta 1

7045

TGFBI

transforming growth factor, beta-induced, 68kDa

7046

TGFBR1

transforming growth factor, beta receptor 1

7048

TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

7049

TGFBR3

transforming growth factor, beta receptor III

7054

TH

tyrosine hydroxylase

7057

THBS1

thrombospondin 1

7076

TIMP1

TIMP metallopeptidase inhibitor 1

7124

TNF

tumor necrosis factor

7157

TP53

tumor protein p53

7166

TPH1

tryptophan hydroxylase 1

718

C3

complement component 3

7222

TRPC3

transient receptor potential cation channel, subfamily C, member 3

7223

TRPC4

transient receptor potential cation channel, subfamily C, member 4

7225

TRPC6

transient receptor potential cation channel, subfamily C, member 6

724066

ATXN8

ataxin 8

7292

TNFSF4

tumor necrosis factor (ligand) superfamily, member 4

7318

UBA7

ubiquitin-like modifier activating enzyme 7

7412

VCAM1

vascular cell adhesion molecule 1

7422

VEGFA

vascular endothelial growth factor A

7432

VIP

vasoactive intestinal peptide

7433

VIPR1

vasoactive intestinal peptide receptor 1

7434

VIPR2

vasoactive intestinal peptide receptor 2

7450

VWF

von Willebrand factor

7471

WNT1

wingless-type MMTV integration site family, member 1

7474

WNT5A

wingless-type MMTV integration site family, member 5A

7494

XBP1

X-box binding protein 1

7498

XDH

xanthine dehydrogenase

775

CACNA1C

calcium channel, voltage-dependent, L type, alpha 1C subunit

7923

HSD17B8

hydroxysteroid (17-beta) dehydrogenase 8

79895

ATP8B4

ATPase, class I, type 8B, member 4

79924

ADM2

adrenomedullin 2

81839

VANGL1

VANGL planar cell polarity protein 1

8200

GDF5

growth differentiation factor 5

826

CAPNS1

calpain, small subunit 1

841

CASP8

caspase 8, apoptosis-related cysteine peptidase

8412

BCAR3

breast cancer anti-estrogen resistance 3

842

CASP9

caspase 9, apoptosis-related cysteine peptidase

846

CASR

calcium-sensing receptor

84735

CNDP1

carnosine dipeptidase 1 (metallopeptidase M20 family)

857

CAV1

caveolin 1, caveolae protein, 22kDa

8600

TNFSF11

tumor necrosis factor (ligand) superfamily, member 11

8630

HSD17B6

hydroxysteroid (17-beta) dehydrogenase 6

8742

TNFSF12

tumor necrosis factor (ligand) superfamily, member 12

8743

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

8862

APLN

apelin

8996

NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

9034

CCRL2

chemokine (C-C motif) receptor-like 2

9068

ANGPTL1

angiopoietin-like 1

9166

EBAG9

estrogen receptor binding site associated, antigen, 9

94

ACVRL1

activin A receptor type II-like 1

9475

ROCK2

Rho-associated, coiled-coil containing protein kinase 2

9518

GDF15

growth differentiation factor 15

959

CD40LG

CD40 ligand

960

CD44

CD44 molecule (Indian blood group)

961

CD47

CD47 molecule

993

CDC25A

cell division cycle 25A



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